15'20'-anhydrovinblastine

Base Information

• Chemical Name: 15'20'-anhydrovinblastine
• CAS No.: 61246-76-2
• Molecular Formula: C₄₆H₅₆N₄O₈
• Molecular Weight: 792.973
• Mol file: 61246-76-2.mol

Synonyms:

Chemical Property of 15'20'-anhydrovinblastine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15'20'-anhydrovinblastine

There total 16 articles about 15'20'-anhydrovinblastine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

catharanthine + vindoline (2182-14-1) → anhydrovinblastine (38390-45-3,56083-20-6,61246-76-2,105815-31-4)

Guidance literature:

catharanthine; vindoline; With hydrogenchloride; 2,2,2-trifluoroethanol; iron(III) chloride hexahydrate; In water; at 25 ℃; for 2h; Inert atmosphere;

With sodium tetrahydroborate; In water; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ml200236a

Reference yield: 90.0%

catharinthine (2468-21-5) + vindoline (2182-14-1) → anhydrovinblastine (38390-45-3,56083-20-6,61246-76-2,105815-31-4)

Guidance literature:

catharinthine; vindoline; With iron(III) chloride hexahydrate; at 25 ℃;

With sodium tetrahydroborate; at 0 ℃;

DOI:10.1016/j.bmcl.2010.09.091

Reference yield: 85.0%

Catharanthine + vindoline (2182-14-1) → anhydrovinblastine (38390-45-3,56083-20-6,61246-76-2,105815-31-4)

Guidance literature:

Catharanthine; vindoline; With hydrogenchloride; iron(III) chloride; at 35 ℃; aqueous glycine buffer;

With ammonium hydroxide; sodium tetrahydroborate; In water;

DOI:10.1021/jm801064y

upstream raw materials:

Catharanthine hydrogensulfate

vindoline

catharinthine

anhydrovinblastine eniminium

Downstream raw materials:

vinorelbine