2-Amino-N-(4-fluorophenyl)acetamide hydrochloride

Base Information

• Chemical Name: 2-Amino-N-(4-fluorophenyl)acetamide hydrochloride
• CAS No.: 137895-50-2
• Molecular Formula: C8H9FN2O.ClH
• Molecular Weight: 204.62900
• Mol file: 137895-50-2.mol

Synonyms:

Chemical Property of 2-Amino-N-(4-fluorophenyl)acetamide hydrochloride

Chemical Property:

• PSA: 55.12000
• LogP: 2.29820

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-N-(4-fluorophenyl)acetamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-N-(4-fluorophenyl)acetamide hydrochloride

There total 2 articles about 2-Amino-N-(4-fluorophenyl)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

[(4-fluorophenylcarbamoyl)methyl]carbamic acid t-butyl ester → [(4-fluorophenyl)carbamoyl]methanaminium chloride (137895-50-2)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/cmdc.201900687

Reference yield:

4-fluoroaniline (371-40-4) → [(4-fluorophenyl)carbamoyl]methanaminium chloride (137895-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / ethyl acetate / 72 h / 20 °C

2: water; hydrogenchloride / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate;

DOI:10.1002/cmdc.201900687

upstream raw materials:

4-fluoroaniline