3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt

Base Information

Chemical Name:3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt
CAS No.:1318780-10-7
Molecular Formula:C₂HF₃O₂*C₂₄H₁₉ClF₄N₆O₂S
Molecular Weight:680.99
Hs Code.:

3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt

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Chemical Property of 3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt

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Technology Process of 3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt

There total 7 articles about 3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1352576-30-7
N-tert-butyl-3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide

: 76-05-1
trifluoroacetic acid

: 1318780-10-7
3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt

Guidance literature:: With water; at 70 - 80 ℃; for 0.25h;
DOI:10.1021/ml200163b

Reference yield:

: 917758-83-9
3-amino-6-(4-fluorophenyl)pyridine-2-carboxamide

: 1318780-10-7
3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 1 h / 100 °C

2: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 16 h / Reflux

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 19 h / 40 - 80 °C

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 11 h / 120 °C / Microwave irradiation; Sealed vessel

5: water / 0.25 h / 70 - 80 °C

With water; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one;
DOI:10.1021/ml200163b

Reference yield:

: 917758-91-9
6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine-2,4-diol

: 1318780-10-7
3-chloro-5-((6-(4-fluorophenyl)-4-(1-(trifluoromethyl)cyclopropylamino)pyrido[3,2-d]pyrimidin-2-ylamino)methyl)benzenesulfonamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 16 h / Reflux

2: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 19 h / 40 - 80 °C

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 11 h / 120 °C / Microwave irradiation; Sealed vessel

4: water / 0.25 h / 70 - 80 °C

With water; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1-methyl-pyrrolidin-2-one;
DOI:10.1021/ml200163b