(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

Base Information

Chemical Name:(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate
CAS No.:313680-04-5
Molecular Formula:C₃₇H₅₃N₃O₁₂S
Molecular Weight:763.907
Hs Code.:

(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

Synonyms:

Suppliers and Price of (3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

There total 12 articles about (3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162536-84-7
tert-butyl (1S)-2-[4-(benzyloxy)phenyl]-1-[(2S)-oxiranyl]ethylcarbamate

: 313680-04-5
(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: propan-2-ol / Heating

2: DIEA / CH₂Cl₂

3: 100 percent / TFA / CH₂Cl₂

4: 96 percent / DIEA / acetonitrile

5: 98 percent / H₂ / Pd/C / tetrahydrofuran

6: di-t-butylazodicarboxylate; Ph₃P / CH₂Cl₂

With di-tert-butyl-diazodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile; 6: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.129

Reference yield:

: 174801-33-3,1059189-63-7
(2S,3S)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane

: 313680-04-5
(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: KOH / ethanol

2: propan-2-ol / Heating

3: DIEA / CH₂Cl₂

4: 100 percent / TFA / CH₂Cl₂

5: 96 percent / DIEA / acetonitrile

6: 98 percent / H₂ / Pd/C / tetrahydrofuran

7: di-t-butylazodicarboxylate; Ph₃P / CH₂Cl₂

With potassium hydroxide; di-tert-butyl-diazodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; acetonitrile; 7: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.129

Reference yield:

: 313679-52-6
tert-butyl (1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isobutylamino)propylcarbamate

: 313680-04-5
(3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: DIEA / CH₂Cl₂

2: 100 percent / TFA / CH₂Cl₂

3: 96 percent / DIEA / acetonitrile

4: 98 percent / H₂ / Pd/C / tetrahydrofuran

5: di-t-butylazodicarboxylate; Ph₃P / CH₂Cl₂

With di-tert-butyl-diazodicarboxylate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetonitrile; 5: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.05.129