162536-84-7

Basic information

• Product Name: ERYTHRO-N-BOC-O-BENZYL-L-TYROSINE EPOXIDE
• Synonyms: (S)-[1'-(S)-N-BOC AMINO-2-[4-(BENZYLOXY)PHENYL]ETHYL]OXIRANE;ERYTHRO-N-T-BUTOXYCARBONYL-O-BENZYL-L-TYROSINE EPOXIDE;ERYTHRO-N-BOC-O-BENZYL-L-TYROSINE EPOXIDE;[2-(4-BENZYLOXY-PHENYL)-1(S)-(S)OXIRANYL-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER;(1S)-[1'-(S)-N-T-BUTOXYCARBONYL-AMINO-2-[4-(BENZYLOXY)PHENYL]ETHYL]OXIRANE;(1S)-(1'-(S)-N-BOC-AMINO-2-[4-(BENZYLOXY)PHENYL]ETHYL)OXIRANE;(S)-(2S,3R)-3,4-Dihydroxybutan-2-yl 3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)aMino)propanoate;(S)-(2S,3R)-3,4-Dihydroxybutan-2-yl 3-(4-(benzyloxy)-phenyl)-2-((tert-butoxycarbonyl)amino)propan
• CAS NO: 162536-84-7
• Molecular Formula: C₂₂H₂₇NO₄
• Molecular Weight: 369.45
• Product Categories: Chiral Amino Epoxides
• Mol File: 162536-84-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 528.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.153±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.04±0.46(Predicted)
• CAS DataBase Reference: ERYTHRO-N-BOC-O-BENZYL-L-TYROSINE EPOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ERYTHRO-N-BOC-O-BENZYL-L-TYROSINE EPOXIDE(162536-84-7)
• EPA Substance Registry System: ERYTHRO-N-BOC-O-BENZYL-L-TYROSINE EPOXIDE(162536-84-7)

Safety Data

• Hazardous Substances Data: 162536-84-7(Hazardous Substances Data)

Usage

General Description

Erythro-N-Boc-O-benzyl-L-tyrosine epoxide is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a derivative of tyrosine, an amino acid that plays a crucial role in protein synthesis and various physiological functions. The compound is synthesized by reacting erythro-N-Boc-O-benzyl-L-tyrosine with an epoxide, resulting in a molecule with a reactive epoxide group attached to the tyrosine side chain. This chemical modification can confer desirable properties to the molecule, such as increased solubility or reactivity, making it useful for the development of new drugs or as a building block in organic synthesis. Additionally, the compound has potential as a drug candidate due to its ability to target specific cellular pathways or biochemical processes.

Upstream product

• 152438-62-5 (S)-N-[3-Chloro-2-oxo-1-[[4-(phenylmethoxy)phenyl]methyl]propyl]carbamic acid 1,1-dimethylethyl ester 
• 127132-32-5 ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-O-(phenylmethyl)-L-tyrosinate 
• 174801-33-3 (2S,3S)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane 

Downstream Products

• 313679-52-6 tert-butyl (1S,2R)-1-[4-(benzyloxy)benzyl]-2-hydroxy-3-(isobutylamino)propylcarbamate 
• 162536-85-8 (2S,3S)-N-tert-butoxycarbonyl-3-amino-1,2-epoxy-4-(4-hydroxyphenyl)butane 
• 313680-04-5 (3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{4-[(tert-butoxycarbonyl)amino]butoxy}benzyl)-2-hydroxypropylcarbamate 
• 313680-02-3 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{3-[(tert-butoxycarbonyl)amino]propoxy}benzyl)-2-hydroxypropylcarbamate 
• 313680-00-1 (3R,3AS,6AR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-(4-{2-[(tert-butoxycarbonyl)amino]ethoxy}benzyl)-2-hydroxypropylcarbamate 
• 313680-05-6 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl (1S,2R)-1-[4-(4-aminobutoxy)benzyl]-3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl) amino]-2-hydroxypropylcarbamate 

Relevant articles and documents

Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles

A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two protease inhibitor-resistant viruses. All of the compounds had wild-type antiviral activities that were similar to or greater than several currently marketed HIV protease inhibitors. In addition, a number of compounds in this series were more potent against the drug-resistant mutant viruses than they were against wild-type virus.