Technology Process of 3-{4-[({4'-[2-(ethylsulfonyl)ethoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoic acid methanesulfonate
There total 11 articles about 3-{4-[({4'-[2-(ethylsulfonyl)ethoxy]-2',6'-dimethylbiphenyl-3-yl}methyl)amino]-2-fluorophenyl}propanoic acid methanesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trifluoroacetic acid / toluene / 20 °C
2: diethyl ether; ethyl acetate / 20 °C
With
trifluoroacetic acid;
In
diethyl ether; ethyl acetate; toluene;
DOI:10.1021/jm2016123
- Guidance literature:
-
Multi-step reaction with 8 steps
1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0 °C
2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C
4: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C
5: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0 - 20 °C
6: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 20 °C
7: trifluoroacetic acid / toluene / 20 °C
8: diethyl ether; ethyl acetate / 20 °C
With
sodium tetrahydroborate; lithium hydroxide monohydrate; tributylphosphine; tetrabutyl ammonium fluoride; mercaptoacetic acid; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2016123
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / tetrahydrofuran / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0 - 20 °C
3: lithium hydroxide monohydrate; mercaptoacetic acid / N,N-dimethyl-formamide / 20 °C
4: trifluoroacetic acid / toluene / 20 °C
5: diethyl ether; ethyl acetate / 20 °C
With
lithium hydroxide monohydrate; tributylphosphine; mercaptoacetic acid; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2016123
