C₁₈H₂₈ClN₃OSi

Base Information

Chemical Name:C₁₈H₂₈ClN₃OSi
CAS No.:1621619-13-3
Molecular Formula:C₁₈H₂₈ClN₃OSi
Molecular Weight:365.978
Hs Code.:

C<sub>18</sub>H<sub>28</sub>ClN<sub>3</sub>OSi

Synonyms:

Suppliers and Price of C₁₈H₂₈ClN₃OSi

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
rel-7-((1r,4r)-4-((tert-Butyldimethylsilyl)oxy)cyclohexyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidine 95%+
250mg
$ 1853.00

Chemenu
rel-7-((1r,4r)-4-((tert-Butyldimethylsilyl)oxy)cyclohexyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidine 95%+
100mg
$ 1112.00

Total 2 raw suppliers

Chemical Property of C₁₈H₂₈ClN₃OSi

Chemical Property:

Density:1.16±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

rel-7-((1r,4r)-4-((tert-Butyldimethylsilyl)oxy)cyclohexyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidine 95%+ ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₁₈H₂₈ClN₃OSi

There total 8 articles about C₁₈H₂₈ClN₃OSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

: 1621619-12-2
C₁₂H₁₄ClN₃O

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1621619-13-3
C₁₈H₂₈ClN₃OSi

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;
DOI:10.1039/c7cc07581b

Reference yield: 89.0%

: 1621619-12-2
trans-4-(2-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1621619-13-3
7-(trans-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm500749d

Reference yield:

: trans-4-((5-bromo-2-chloropyrimidin-4-yl)amino)cyclohexan-1-ol

: 1621619-13-3
7-(trans-4-((tert-butyldimethylsilyl)oxy)cyclohexyl)-2-chloro-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / toluene / 2.5 h / 60 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 65 °C

3: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 1: |Sonogashira Cross-Coupling;
DOI:10.1021/jm500749d