Technology Process of 1,3-di-N-benzyl-1,3-di-N-benzyloxycarbonyl-4-O-<6-benzyloxycarbonylamino-4-O-(6-benzyloxycarbonylamino-2,3,6-trideoxy-α-D-erythro-hexopyranosyl)-2,3,6-trideoxy-α-D-erythro-hexopyranosyl>-5,6-O-cyclohexylidene-2-deoxystreptamine
There total 14 articles about 1,3-di-N-benzyl-1,3-di-N-benzyloxycarbonyl-4-O-<6-benzyloxycarbonylamino-4-O-(6-benzyloxycarbonylamino-2,3,6-trideoxy-α-D-erythro-hexopyranosyl)-2,3,6-trideoxy-α-D-erythro-hexopyranosyl>-5,6-O-cyclohexylidene-2-deoxystreptamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: periodic acid / tetrahydrofuran / 1 h
2: 0.15 g / triethylamine / methanol / 24 h / 25 °C
3: 81 percent / sodium methoxide / methanol / 2 h / 70 °C
4: 75 percent / boron trifluoride etherate, triethylamine / CHCl3 / 2 h / -5 °C
5: 92 mg / hydrogen / 10 percent Pd-C / methanol / 3 h / 1520 Torr
6: 35 mg / MeONa / methanol
7: 1) CCl4, tris(dimethylamino)phosphine 2) sodium azide / 1) N,N-dimethylformamid, -45 deg C, 1.5 h 2) 60 deg C, 48 h
8: 88 percent / BF3-etherate, 6-toluene-p-sulphonate, sodium azide, triethylamine / 1,2-dichloro-ethane; dimethylformamide / 1.5 h / -5 °C
9: 96 percent / MeONa / methanol
With
tetrachloromethane; sodium azide; 6-toluene-p-sulphonate; boron trifluoride diethyl etherate; hydrogen; sodium methylate; periodic acid; triethylamine; Hexamethylphosphorous triamide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)90217-9
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 0.15 g / triethylamine / methanol / 24 h / 25 °C
2: 81 percent / sodium methoxide / methanol / 2 h / 70 °C
3: 75 percent / boron trifluoride etherate, triethylamine / CHCl3 / 2 h / -5 °C
4: 92 mg / hydrogen / 10 percent Pd-C / methanol / 3 h / 1520 Torr
5: 35 mg / MeONa / methanol
6: 1) CCl4, tris(dimethylamino)phosphine 2) sodium azide / 1) N,N-dimethylformamid, -45 deg C, 1.5 h 2) 60 deg C, 48 h
7: 88 percent / BF3-etherate, 6-toluene-p-sulphonate, sodium azide, triethylamine / 1,2-dichloro-ethane; dimethylformamide / 1.5 h / -5 °C
8: 96 percent / MeONa / methanol
With
tetrachloromethane; sodium azide; 6-toluene-p-sulphonate; boron trifluoride diethyl etherate; hydrogen; sodium methylate; triethylamine; Hexamethylphosphorous triamide;
palladium on activated charcoal;
In
methanol; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)90217-9
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 81 percent / 1:1 acetic acid / 7 h / 56 °C
2: periodic acid / tetrahydrofuran / 1 h
3: 0.15 g / triethylamine / methanol / 24 h / 25 °C
4: 81 percent / sodium methoxide / methanol / 2 h / 70 °C
5: 75 percent / boron trifluoride etherate, triethylamine / CHCl3 / 2 h / -5 °C
6: 92 mg / hydrogen / 10 percent Pd-C / methanol / 3 h / 1520 Torr
7: 35 mg / MeONa / methanol
8: 1) CCl4, tris(dimethylamino)phosphine 2) sodium azide / 1) N,N-dimethylformamid, -45 deg C, 1.5 h 2) 60 deg C, 48 h
9: 88 percent / BF3-etherate, 6-toluene-p-sulphonate, sodium azide, triethylamine / 1,2-dichloro-ethane; dimethylformamide / 1.5 h / -5 °C
10: 96 percent / MeONa / methanol
With
tetrachloromethane; sodium azide; 6-toluene-p-sulphonate; boron trifluoride diethyl etherate; hydrogen; sodium methylate; acetic acid; periodic acid; triethylamine; Hexamethylphosphorous triamide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0008-6215(00)90217-9
