3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol

Base Information

• Chemical Name: 3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol
• CAS No.: 132277-51-1
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.284
• Mol file: 132277-51-1.mol

Synonyms:

Chemical Property of 3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol

There total 7 articles about 3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Allyl-3-methoxy-6-methoxymethoxy-2-methyl-phenol → 3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol (132277-51-1)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 105 ℃;

DOI:10.1016/S0040-4039(00)98010-9

Reference yield:

2-hydroxy-4-methoxy-3-methylbenzaldehyde (54700-36-6) → 3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol (132277-51-1)

Guidance literature:

Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide / 80 °C

2: 30percent H₂O₂, SeO₂ / 2-methyl-propan-2-ol / 40 °C

3: Et₃N, MeOH / 23 °C

4: i-Pr₂NEt / CH₂Cl₂ / 80 °C

5: various solvent(s) / 210 °C

6: KOH / dimethylsulfoxide / 105 °C

With methanol; potassium hydroxide; selenium(IV) oxide; dihydrogen peroxide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0040-4039(00)98010-9

Reference yield:

2,4-dimethoxy-3-methylbenzaldehyde (7149-92-0) → 3-Methoxy-6-methoxymethoxy-2-methyl-4-((E)-propenyl)-phenol (132277-51-1)

Guidance literature:

Multi-step reaction with 7 steps

1: BCl₃ / CH₂Cl₂ / 0 °C

2: K₂CO₃ / dimethylformamide / 80 °C

3: 30percent H₂O₂, SeO₂ / 2-methyl-propan-2-ol / 40 °C

4: Et₃N, MeOH / 23 °C

5: i-Pr₂NEt / CH₂Cl₂ / 80 °C

6: various solvent(s) / 210 °C

7: KOH / dimethylsulfoxide / 105 °C

With methanol; potassium hydroxide; selenium(IV) oxide; dihydrogen peroxide; boron trichloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;

DOI:10.1016/S0040-4039(00)98010-9

upstream raw materials:

2-hydroxy-4-methoxy-3-methylbenzaldehyde

2,4-dimethoxy-3-methylbenzaldehyde

2-Allyloxy-4-methoxy-3-methyl-benzaldehyde

2-Allyloxy-4-methoxy-1-methoxymethoxy-3-methyl-benzene