Tetrahydrorhombifoline

Base Information

Chemical Name:Tetrahydrorhombifoline
CAS No.:3382-84-1
Molecular Formula:C₁₅H₂₄N₂O
Molecular Weight:248.368
Hs Code.:2933990090
ChEMBL ID:CHEMBL460224
Nikkaji Number:J398.670E
Wikidata:Q104253253

Synonyms:Tetrahydrorhombifoline;3382-84-1;1,5-Methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one, 3-(3-butenyl)decahydro-, (1S-(1alpha,5alpha,11aalpha))-;tetrahydrorombifoline;CHEMBL460224;HY-N12343;CS-0898481;NS00094234

Suppliers and Price of Tetrahydrorhombifoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Tetrahydrorhombifoline

Chemical Property:

Vapor Pressure:3.98E-06mmHg at 25°C
Boiling Point:384.8°C at 760 mmHg
Flash Point:162°C
PSA：23.55000
Density:1.09g/cm³
LogP:1.77110
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:248.188863393
Heavy Atom Count:18
Complexity:341

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CCCN1CC2CC(C1)C3CCCC(=O)N3C2
Isomeric SMILES:C=CCCN1C[C@H]2C[C@@H](C1)[C@H]3CCCC(=O)N3C2

Technology Process of Tetrahydrorhombifoline

There total 8 articles about Tetrahydrorhombifoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: ent-tetrahydrocytisine

: 106-95-6
allyl bromide

: 3382-84-1
(+)-Tetrahydrorhombifoline

Guidance literature:: With copper(l) iodide; acetic acid; zinc; In water; at 20 ℃; for 22h;
DOI:10.1002/anie.201712852

Reference yield:

: 6-methyl-3,7-diazabicyclo[3.3.1]non-6-en-2-one

: 3382-84-1
(+)-Tetrahydrorhombifoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dmap / dichloromethane / 20 h

2.1: triethylamine / tetrahydrofuran / 5 h / 20 °C

3.1: Adam’s catalyst; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr

4.1: methanol; sodium tetrahydroborate / dichloromethane / 2 h / 0 - 20 °C

4.2: 17 h / -78 - 20 °C

5.1: acetic acid; zinc; copper(l) iodide / water / 22 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; copper(l) iodide; Adam’s catalyst; hydrogen; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/anie.201712852

Reference yield:

: 3-tert-butoxycarbonyl-6-methyl-3,7-diazabicyclo[3.3.1]non-6-en-2-one

: 3382-84-1
(+)-Tetrahydrorhombifoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 5 h / 20 °C

2.1: Adam’s catalyst; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr

3.1: methanol; sodium tetrahydroborate / dichloromethane / 2 h / 0 - 20 °C

3.2: 17 h / -78 - 20 °C

4.1: acetic acid; zinc; copper(l) iodide / water / 22 h / 20 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; Adam’s catalyst; hydrogen; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/anie.201712852