2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene

Base Information

Chemical Name:2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene
CAS No.:117967-85-8
Molecular Formula:C₂₉H₂₂OS
Molecular Weight:418.559
Hs Code.:

Synonyms:

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Chemical Property of 2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene

Chemical Property:

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Technology Process of 2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene

There total 7 articles about 2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119247-16-4
2-(4-methoxy-phenyl)-3,4,5-triphenyl-cyclopentadienone

: 117967-85-8
2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene

Guidance literature:: With sulfur; at 320 ℃; unter Kohlendioxid;

Reference yield:

: 19282-39-4
ethyl 5-phenylthiophene-2-carboxylate

: 117967-85-8
2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; zinc(II) chloride; bromine / 1 h / 60 °C

2.1: potassium carbonate; palladium dichloride / water; ethanol / 0.5 h / 60 °C

3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran; toluene / 1.25 h / 0 - 20 °C / Inert atmosphere

3.2: 1.25 h / 0 - 20 °C / Inert atmosphere

4.1: potassium carbonate; palladium dichloride / water; ethanol / 1 h / 60 °C

5.1: sodium hydroxide / ethanol / 0.5 h / Reflux

6.1: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 170 °C / Microwave irradiation; Sealed tube

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; bis(tri-t-butylphosphine)palladium⁽⁰⁾; bromine; potassium carbonate; caesium carbonate; acetic acid; sodium hydroxide; palladium dichloride; zinc(II) chloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.orglett.1c02447

Reference yield:

: C₁₉H₁₅IO₂S

: 117967-85-8
2-(4-methoxy-phenyl)-3,4,5-triphenyl-thiophene

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; palladium dichloride / water; ethanol / 1 h / 60 °C

2: sodium hydroxide / ethanol / 0.5 h / Reflux

3: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 170 °C / Microwave irradiation; Sealed tube

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium carbonate; caesium carbonate; sodium hydroxide; palladium dichloride; In ethanol; water; N,N-dimethyl-formamide; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.orglett.1c02447