Technology Process of (tert-butyl)({(2S,3S,4S)-2-ethyl-3-[(4-methoxybenzyl)oxy]-4-methylhex-5-en-1-yl}oxy)diphenylsilane
There total 9 articles about (tert-butyl)({(2S,3S,4S)-2-ethyl-3-[(4-methoxybenzyl)oxy]-4-methylhex-5-en-1-yl}oxy)diphenylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(methylidene)triphenylphosphonium iodide;
With
potassium tert-butylate;
In
tetrahydrofuran;
at -5 - 0 ℃;
for 3h;
C32H42O4Si;
In
tetrahydrofuran;
at 0 ℃;
for 3h;
DOI:10.1002/hlca.201300326
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 10 h / 0 - 20 °C
2.1: dichloromethane / 3 h / 0 - 20 °C
3.1: 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C
4.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -10 - 0 °C
5.1: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; Cumene hydroperoxide / dichloromethane / 3 h / -20 °C / Molecular sieve
6.1: copper(l) iodide / hexane; diethyl ether / 20 h / -20 °C
6.2: 10 h / 20 °C
7.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C
8.1: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -20 - 0 °C
9.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
9.2: -30 °C
10.1: potassium tert-butylate / tetrahydrofuran / 3 h / -5 - 0 °C
10.2: 3 h / 0 °C
With
1H-imidazole; titanium(IV) isopropylate; sodium periodate; copper(l) iodide; oxalyl dichloride; Cumene hydroperoxide; potassium tert-butylate; diisobutylaluminium hydride; sodium hydrogencarbonate; D-(-)-diisopropyl tartrate; toluene-4-sulfonic acid; dimethyl sulfoxide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water;
2.1: |Wittig Olefination / 5.1: |Sharpless Asymmetric Epoxidation / 9.1: |Swern Oxidation / 9.2: |Swern Oxidation / 10.1: |Wittig Olefination / 10.2: |Wittig Olefination;
DOI:10.1002/hlca.201300326
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole / dichloromethane / 3 h / 0 - 20 °C
2.1: diisobutylaluminium hydride / dichloromethane; hexane / 2 h / -10 - 0 °C
3.1: D-(-)-diisopropyl tartrate; titanium(IV) isopropylate; Cumene hydroperoxide / dichloromethane / 3 h / -20 °C / Molecular sieve
4.1: copper(l) iodide / hexane; diethyl ether / 20 h / -20 °C
4.2: 10 h / 20 °C
5.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C
6.1: diisobutylaluminium hydride / dichloromethane; hexane / 3 h / -20 - 0 °C
7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
7.2: -30 °C
8.1: potassium tert-butylate / tetrahydrofuran / 3 h / -5 - 0 °C
8.2: 3 h / 0 °C
With
1H-imidazole; titanium(IV) isopropylate; copper(l) iodide; oxalyl dichloride; Cumene hydroperoxide; potassium tert-butylate; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate; toluene-4-sulfonic acid; dimethyl sulfoxide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
3.1: |Sharpless Asymmetric Epoxidation / 7.1: |Swern Oxidation / 7.2: |Swern Oxidation / 8.1: |Wittig Olefination / 8.2: |Wittig Olefination;
DOI:10.1002/hlca.201300326
