N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide

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Chemical Name:N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide
CAS No.:123887-50-3
Molecular Formula:C₂₆H₃₈N₂O₃S
Molecular Weight:458.665
Hs Code.:

Synonyms:

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Chemical Property of N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide

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Technology Process of N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide

There total 17 articles about N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37845-64-0
2-Cyanoethyl 2-(Methylamino)phenyl Sulfide

: 123887-64-9
Acetic acid 2-[(1R,3R,6R)-3-(2-chlorocarbonyl-ethyl)-2,2,6-trimethyl-cyclohexyl]-ethyl ester

: 123887-50-3
N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 0 ℃; for 0.166667h; Yield given;
DOI:10.1248/cpb.36.4711

Reference yield:

: 123887-37-6,123906-77-4
bicyclic hemiacetal of 4α-formyl-6α-hydroxymethyl-1,5,5-trimethylcyclohexene

: 123887-50-3
N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide

Guidance literature:: Multi-step reaction with 13 steps

1: 70.5 percent / toluene / 24 h / 100 °C

2: 97.3 percent / PtO₂, hydrogen / ethyl acetate / 2 h / Ambient temperature

3: 100 percent / Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

4: dimethylsulfoxide / 7 h / 100 - 105 °C

5: 240 mg / LiBH₄ / diethyl ether / 3 h / Heating

6: pyridinium p-toluenesulfonate / CH₂Cl₂ / 13 h / Ambient temperature

7: 185 mg / diisobutylaluminum hydride / hexane; toluene / 1 h / Ambient temperature

8: 176 mg / 1.) LiAlH₄; 2.) NaOH, water / diethyl ether / 0.5 h / -15 °C

9: 179 mg / pyridine / 1 h / Ambient temperature

10: p-TsOH / ethanol / 3 h / Ambient temperature

11: Jones reagent / acetone / 0.5 h / Ambient temperature

12: oxalyl chloride / benzene / 1 h / 60 °C

13: K₂CO₃ / tetrahydrofuran / 0.17 h / 0 °C

With platinum(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; lithium borohydride; jones reagent; oxalyl dichloride; water; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; pyridine; diethyl ether; ethanol; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetone; toluene; benzene;
DOI:10.1248/cpb.36.4711

Reference yield:

: 123887-47-8
3-(3α-cyanomethyl-2,2,4α-trimethylcyclohexan-1α-yl)propan-1-ol

: 123887-50-3
N-methyl-2'-<(2-cyanoethyl)thio>-3-<3α-(2-acetoxyethyl)-2,2,4α-trimethylcyclohexan-1α-yl>propionanilide

Guidance literature:: Multi-step reaction with 8 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 13 h / Ambient temperature

2: 185 mg / diisobutylaluminum hydride / hexane; toluene / 1 h / Ambient temperature

3: 176 mg / 1.) LiAlH₄; 2.) NaOH, water / diethyl ether / 0.5 h / -15 °C

4: 179 mg / pyridine / 1 h / Ambient temperature

5: p-TsOH / ethanol / 3 h / Ambient temperature

6: Jones reagent / acetone / 0.5 h / Ambient temperature

7: oxalyl chloride / benzene / 1 h / 60 °C

8: K₂CO₃ / tetrahydrofuran / 0.17 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; jones reagent; oxalyl dichloride; water; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; pyridine; diethyl ether; ethanol; hexane; dichloromethane; acetone; toluene; benzene;
DOI:10.1248/cpb.36.4711