sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

Base Information

Chemical Name:sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate
CAS No.:84164-45-4
Molecular Formula:C₂₁H₂₁N₆O₁₂S₂*Na
Molecular Weight:636.553
Hs Code.:

sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

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Chemical Property of sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

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Technology Process of sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

There total 34 articles about sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 84164-44-3,84518-02-5
sodium trans-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

: 84164-45-4,84368-45-6
sodium trans-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

Guidance literature:: With sodium N-methyldithiocarbamate; In water; for 2h; Ambient temperature;
DOI:10.1248/cpb.32.2646

Reference yield: 69.0%

: 84164-44-3,84518-02-5
sodium cis-3-<2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

: 84164-45-4,84368-45-6
sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

Guidance literature:: With sodium N-methyldithiocarbamate; In water; for 2h; Ambient temperature;
DOI:10.1248/cpb.32.2646

Reference yield:

: 61964-78-1,84187-43-9,88792-16-9,88792-17-0,88852-05-5,97591-35-0
cis-3-amino-1-(2,4-dimethoxybenzyl)-4-methoxycarbonyl-2-azetidinone

: 84164-45-4,84368-45-6
sodium cis-3-<2-(2-aminothiazol-4-yl)-(Z)-2-<1-methyl-1-(4-nitrobenzyloxycarbonyl)ethoxyimino>acetamido>-4-methoxycarbonyl-2-azetidinone-1-sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: propylene oxide / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 79 percent / <1.6 molar equiv. K₂S₂O₈, K₂HPO₄ / acetonitrile; H₂O / 2 h / Heating

3: 92 percent / hydrogen / 5percent Pd-C / ethanol / 1 h / Ambient temperature

4: 77 percent / NaHCO₃ / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

5: 77 percent / 1.69 M SO₃*DMF / dimethylformamide / 24 h / 5 °C

6: 69 percent / sodium N-methyldithiocarbamate / H₂O / 2 h / Ambient temperature

With sodium N-methyldithiocarbamate; dipotassium hydrogenphosphate; dipotassium peroxodisulfate; sulfur trioxide; hydrogen; sodium hydrogencarbonate; methyloxirane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1248/cpb.32.2646