1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one

Base Information

• Chemical Name: 1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one
• CAS No.: 151692-14-7
• Molecular Formula: C₁₉H₁₈N₂O₂
• Molecular Weight: 306.364
• Mol file: 151692-14-7.mol

Synonyms:

Chemical Property of 1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one

There total 8 articles about 1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one (151692-12-5) → 1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one (151692-14-7)

Guidance literature:

With formic acid; air; at 60 ℃; for 4h;

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → 1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one (151692-14-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 63 percent / potassium tert-butoxide / dimethylformamide; 2-methyl-propan-2-ol / 6 h / Ambient temperature

2: 1) NaH / 1) DMF, 0 deg C, 30 min, 2) DMF, rt, 2 h

3: 88 percent / N₂H₄*H₂O / dimethylformamide / 1 h / Ambient temperature

4: 88 percent / NEt₃, 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

5: 66 percent / lithium tri-tert-butoxyaluminiumhydride / tetrahydrofuran; hexane / 1 h / 0 °C

6: 75 percent / H₂ / 10percent Pd/C / ethanol / 24 h / 3040 Torr

7: 74 percent / formic acid, air / 4 h / 60 °C

With dmap; formic acid; air; potassium tert-butylate; hydrogen; sodium hydride; hydrazine hydrate; lithium tri-t-butoxyaluminum hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

(Z)-1-acetyl-3-(3-methoxy-benzylidene)-piperazine-2,5-dione (151692-02-3) → 1-benzyl-6-(3-methoxybenzyl)pyrazin-2(1H)-one (151692-14-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 1) NaH / 1) DMF, 0 deg C, 30 min, 2) DMF, rt, 2 h

2: 88 percent / N₂H₄*H₂O / dimethylformamide / 1 h / Ambient temperature

3: 88 percent / NEt₃, 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

4: 66 percent / lithium tri-tert-butoxyaluminiumhydride / tetrahydrofuran; hexane / 1 h / 0 °C

5: 75 percent / H₂ / 10percent Pd/C / ethanol / 24 h / 3040 Torr

6: 74 percent / formic acid, air / 4 h / 60 °C

With dmap; formic acid; air; hydrogen; sodium hydride; hydrazine hydrate; lithium tri-t-butoxyaluminum hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

3-methoxy-benzaldehyde

(Z)-1-acetyl-3-(3-methoxy-benzylidene)-piperazine-2,5-dione

4-benzyl-3-(3-methoxybenzylidene)piperazine-2,5-dione

Downstream raw materials:

6-(3-methoxybenzyl)pyrazin-2(1H)-one