1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

Base Information

Chemical Name:1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one
CAS No.:151692-12-5
Molecular Formula:C₂₄H₃₀N₂O₅
Molecular Weight:426.513
Hs Code.:

Synonyms:1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

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Chemical Property of 1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

Chemical Property:

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Technology Process of 1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

There total 9 articles about 1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 151692-08-9
1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzylidene)piperazin-2-one

: 151692-12-5
1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 24h; under 3040 Torr;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 151692-12-5
1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 22 percent / NEt₃, 4-dimethylaminopyridine / pyridine / 12 h / 60 °C

2: 64 percent / potassium fluoride-alumina / 0.25 h / Irradiation; microwaves

3: 1) NaH / 1) DMF, 0 deg C, 30 min, 2) DMF, rt, 2 h

4: 66 percent / lithium tri-tert-butoxyaluminiumhydride / tetrahydrofuran; hexane / 1 h / 0 °C

5: 75 percent / H₂ / 10percent Pd/C / ethanol / 24 h / 3040 Torr

With dmap; potassium fluoride on basic alumina; hydrogen; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol; hexane;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 151692-12-5
1-benzyl-4-tert-butoxycarbonyl-5-hydroxy-6-(3-methoxybenzyl)piperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 63 percent / potassium tert-butoxide / dimethylformamide; 2-methyl-propan-2-ol / 6 h / Ambient temperature

2: 1) NaH / 1) DMF, 0 deg C, 30 min, 2) DMF, rt, 2 h

3: 88 percent / N₂H₄*H₂O / dimethylformamide / 1 h / Ambient temperature

4: 88 percent / NEt₃, 4-dimethylaminopyridine / CH₂Cl₂ / 1 h / Ambient temperature

5: 66 percent / lithium tri-tert-butoxyaluminiumhydride / tetrahydrofuran; hexane / 1 h / 0 °C

6: 75 percent / H₂ / 10percent Pd/C / ethanol / 24 h / 3040 Torr

With dmap; potassium tert-butylate; hydrogen; sodium hydride; hydrazine hydrate; lithium tri-t-butoxyaluminum hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;