(S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester

Base Information

• Chemical Name: (S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester
• CAS No.: 94978-41-3
• Molecular Formula: C₂₁H₃₁NO₆
• Molecular Weight: 393.48
• Mol file: 94978-41-3.mol

Synonyms:

Chemical Property of (S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester

There total 2 articles about (S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4aS,10aS)-4a-(5,5-Dimethoxy-4,4-dimethyl-pentyl)-2,3,4a,7,10,10a-hexahydro-1H-9-oxa-3a-aza-benzo[f]azulen-4-one (94978-39-9) → (S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester (94978-41-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrochloric acid/methanol

2: sodium bicarbonate

With hydrogenchloride; methanol; sodium hydrogencarbonate;

DOI:10.1021/jo00206a049

Reference yield:

(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarboxylic acid (S)-1-pyrrolidin-2-ylmethyl ester (94978-40-2) + methyl chloroformate (79-22-1) → (S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester (94978-41-3)

Guidance literature:

With sodium hydrogencarbonate;

DOI:10.1021/jo00206a049

Reference yield:

(S)-2-[(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester (94978-41-3) → (S)-5-Bromo-1-(5,5-dimethoxy-4,4-dimethyl-pentyl)-6,6-dimethoxy-cyclohex-2-enecarboxylic acid methyl ester (94978-29-7,94978-30-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen chloride / methanol / Heating

2: sodium methoxide

3: N-bromoacetamide / methanol

With hydrogenchloride; sodium methylate; N-bromoacetamide; In methanol;

DOI:10.1021/jo00206a049

upstream raw materials:

(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohex-2-enecarboxylic acid (S)-1-pyrrolidin-2-ylmethyl ester

methyl chloroformate

(4aS,10aS)-4a-(5,5-Dimethoxy-4,4-dimethyl-pentyl)-2,3,4a,7,10,10a-hexahydro-1H-9-oxa-3a-aza-benzo[f]azulen-4-one

Downstream raw materials:

(S)-2-[(S)-1-(5,5-Dimethoxy-4,4-dimethyl-pentyl)-2-methoxy-cyclohexa-2,5-dienecarbonyloxymethyl]-pyrrolidine-1-carboxylic acid methyl ester

(S)-1-(4,4-Dimethyl-5-oxo-pentyl)-6-oxo-cyclohexa-2,4-dienecarboxylic acid methyl ester

(S)-1-(4-Cyano-4,4-dimethyl-butyl)-6-oxo-cyclohexa-2,4-dienecarboxylic acid methyl ester

(S)-1-(5,5-Dimethoxy-4,4-dimethyl-pentyl)-6-oxo-cyclohexa-2,4-dienecarboxylic acid methyl ester