1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

Base Information

Chemical Name:1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt
CAS No.:145256-97-9
Molecular Formula:C₂HF₃O₂*C₂₁H₁₇F₃N₄O₃
Molecular Weight:544.41
Hs Code.:

1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

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Chemical Property of 1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

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Technology Process of 1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

There total 7 articles about 1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140195-93-3
1-(2-Benzyloxycarbonylamino-acetylamino)-cyclopropanecarboxylic acid ethyl ester

: 145256-97-9
1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethanol / 18 h / 3040 Torr

2: 1.) borane*THF complex 2.) HCl / 1.) THF, 60 deg C, 20 h 2.) methanol, reflux, 2 h

3: 53 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene, 1-methyl-2-pyrrolidinone / 100 °C

4: 6 N HCl, trifluoroacetic acid

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; borane-THF; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1139/v92-171

Reference yield:

: 145122-59-4
[(1-benzyloxycarbonylaminocyclopropanecarbonyl)amino]acetic acid ethyl ester

: 145256-97-9
1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 18 h / 3040 Torr

2: DBU / toluene / 22 h / 115 °C

3: 1.) borane*THF complex 2.) HCl / 1.) THF, 60 deg C, 20 h 2.) methanol, reflux, 2 h

4: 53 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene, 1-methyl-2-pyrrolidinone / 100 °C

5: 6 N HCl, trifluoroacetic acid

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; borane-THF; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1139/v92-171

Reference yield:

: 129306-16-7
[(1-Amino-cyclopropanecarbonyl)-amino]-acetic acid ethyl ester

: 145256-97-9
1-(2,4-difluorophenyl)-6-fluoro-7-(4,7-diazaspiro<2,5>octan-7-yl)-1,4-dihydro-4-oxo<1,8>naphthyridine-3-carboxylic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: DBU / toluene / 22 h / 115 °C

2: 1.) borane*THF complex 2.) HCl / 1.) THF, 60 deg C, 20 h 2.) methanol, reflux, 2 h

3: 53 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene, 1-methyl-2-pyrrolidinone / 100 °C

4: 6 N HCl, trifluoroacetic acid

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; borane-THF; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In toluene;
DOI:10.1139/v92-171