2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione

Base Information

Chemical Name:2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione
CAS No.:748814-06-4
Molecular Formula:C₃₉H₃₇N₃O₂
Molecular Weight:579.742
Hs Code.:

Synonyms:

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Chemical Property of 2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione

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Technology Process of 2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione

There total 6 articles about 2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5428-09-1
3-phthalimido-1-propene

: 748814-06-4
2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 9-BBN; K₂CO₃; DPPF / Pd(OAc)2 / dimethylformamide

2: 9-BBN; K₂CO₃; DPPF / Pd(OAc)2 / tetrahydrofuran; dimethylformamide

With 1,1'-bis-(diphenylphosphino)ferrocene; 9-borabicyclo[3.3.1]nonane dimer; potassium carbonate; palladium diacetate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Heck coupling / 2: Heck coupling;
DOI:10.1016/j.bmcl.2004.06.040

Reference yield:

: 76-83-5
trityl chloride

: 748814-06-4
2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / CH₂Cl₂

2: LiAlH₄ / tetrahydrofuran

3: pyridine-SO₃; Et₃N / dimethylsulfoxide; CH₂Cl₂

4: n-BuLi / tetrahydrofuran / 0 °C

5: 9-BBN; K₂CO₃; DPPF / Pd(OAc)2 / tetrahydrofuran; dimethylformamide

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 4: Wittig reaction / 5: Heck coupling;
DOI:10.1016/j.bmcl.2004.06.040

Reference yield:

: 47415-56-5
N-trityl-D-alanine

: 748814-06-4
2-(3-{5-[(R)-3-(Trityl-amino)-butyl]-pyridin-2-yl}-propyl)-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran

2: pyridine-SO₃; Et₃N / dimethylsulfoxide; CH₂Cl₂

3: n-BuLi / tetrahydrofuran / 0 °C

4: 9-BBN; K₂CO₃; DPPF / Pd(OAc)2 / tetrahydrofuran; dimethylformamide

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; sulfur trioxide pyridine complex; potassium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 3: Wittig reaction / 4: Heck coupling;
DOI:10.1016/j.bmcl.2004.06.040