25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

Base Information

Chemical Name:25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide
CAS No.:1208129-85-4
Molecular Formula:C₃₀H₃₇FN₄O₅S
Molecular Weight:584.712
Hs Code.:

25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

Synonyms:

Suppliers and Price of 25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

There total 10 articles about 25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1208129-85-4
25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

Guidance literature:

Reference yield:

: 879498-90-5
1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

: 1208129-85-4
25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

Guidance literature:: Multi-step reaction with 10 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 12 h / 100 °C

3: potassium carbonate / acetonitrile / 20 °C

4: water; lithium hydroxide / tetrahydrofuran; methanol

5: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran

6: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C

7: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C

8: trifluoroacetic acid / dichloromethane / 20 °C

9: acetonitrile

10: 1,8-diazabicyclo[5.4.0]undec-7-ene

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfonamide; water; sodium hydride; potassium carbonate; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki-Miyaura reaction;
DOI:10.1016/j.bmcl.2012.03.097

Reference yield:

: C₂₉H₃₄FNO₅

: 1208129-85-4
25-cyclohexyl-23-fluoro-10,19-dimethyl-5,6,7,8,9,10-hexahydro-2H-14,18:17,20-di(metheno)-1,11,4,10,12,19-benzoxathiatetraazacyclodocosine-3,13(4H,12H,19H)-dione 11,11-dioxide

Guidance literature:: Multi-step reaction with 7 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol

2: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran

3: caesium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C

4: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

6: acetonitrile

7: 1,8-diazabicyclo[5.4.0]undec-7-ene

With sulfonamide; water; caesium carbonate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.03.097