879498-90-5

Basic information

• Product Name: tert-butyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate
• Synonyms: tert-butyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate;2-Bromo-3-cyclohexyl-1H-indole-6-carboxylic acid 1,1-dimethylethyl ester
• CAS NO: 879498-90-5
• Molecular Formula: C₁₉H₂₄BrNO₂
• Molecular Weight: 378.30336
• Mol File: 879498-90-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 479.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.319±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.36±0.30(Predicted)
• CAS DataBase Reference: tert-butyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate(879498-90-5)
• EPA Substance Registry System: tert-butyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate(879498-90-5)

Safety Data

• Hazardous Substances Data: 879498-90-5(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate is a chemical compound with a molecular formula of C19H24BrNO2. It is a derivative of indole, a heterocyclic aromatic organic compound. The presence of a tert-butyl group, a bromine atom, and a carboxylate group in the molecule gives it unique properties and reactivity. This chemical is commonly used in organic synthesis as a building block for the preparation of various pharmaceutical and agrochemical compounds. It may also have potential applications in medicinal chemistry and drug development due to its structural features and biological activities. Additionally, its unique structure may also make it useful in the development of new materials and compounds.

Upstream product

• 494799-76-7 2-bromo-3-cyclohexyl-1H-indole-6-carboxylic acid 
• 507-19-7 t-butyl bromide 
• 879498-89-2 tert-butyl 3-cyclohexyl-1H-indole-6-carboxylate 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 
• 494799-18-7 methyl 3-cyclohexyl-1H-indole-6-carboxylate 
• 494799-17-6 3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid 
• 494799-16-5 3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid 
• 1670-82-2 Indole-6-carboxylic acid 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 108-94-1 cyclohexanone 

Downstream Products

• 879498-80-3 tert-butyl 3-cyclohexyl-2-phenyl-1H-indole-6-carboxylate 
• 1208130-14-6 tert-butyl 2-bromo-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate 
• 1045704-98-0 13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) 6-methyl ester 
• 1384259-13-5 C₃₆H₄₇N₅O₆S 
• 1204417-37-7 C₃₆H₄₉N₅O₆S 
• 1204417-85-5 C₃₆H₄₈N₄O₆S 
• 1384259-12-4 C₃₅H₄₇N₅O₆S 
• 1384259-11-3 C₃₅H₄₆N₄O₆S 
• 1384259-09-9 C₃₈H₅₂N₄O₆S 
• 1384259-23-7 C₃₁H₃₇ClN₄O₅S 
• 1384259-22-6 C₃₁H₃₇FN₄O₆S 
• 928844-30-8 13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester 
• 1204417-50-4 (1aR,12bS)-1a-[(2-{2-[(aminosulfonyl)(methyl)amino]ethoxy}ethyl)(methyl)carbamoyl]-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxylic acid 

Relevant articles and documents

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series

Novel conformationaly constrained 1,6- and 2,6-macrocyclic HCV NS5b polymerase inhibitors, in which either the nitrogen or the phenyl ring in the C2 position of the central indole core is tethered to an acylsulfamide acid bioisostere, have been designed and tested for their anti-HCV potency. This transformational route toward non-zwitterionic finger loop-directed inhibitors led to the discovery of derivatives with improved cell potency and pharmacokinetic profile.

CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS

The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.