Kauran-19-oic acid methyl ester

Base Information

• Chemical Name: Kauran-19-oic acid methyl ester
• CAS No.: 5282-19-9
• Molecular Formula: C₂₁H₃₄O₂
• Molecular Weight: 318.5
• Mol file: 5282-19-9.mol

Synonyms:

Chemical Property of Kauran-19-oic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Kauran-19-oic acid methyl ester

There total 27 articles about Kauran-19-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

ent-kauran-19-oic acid + methyl iodide (74-88-4) → ent-Kauran-19-oic acid-methylester (89495-19-2,5282-19-9)

Guidance literature:

With potassium hydroxide; In acetone; at 25 ℃; for 3.5h;

DOI:10.1021/acs.jafc.6b05159

Reference yield: 37.0%

kaurenoic acid methyl ester (5524-25-4,41473-15-8) → ent-Kauran-19-oic acid-methylester (89495-19-2,5282-19-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; for 24h;

DOI:10.1016/j.bmc.2009.11.064

Reference yield:

(4ar)-2t-Brom-4bt,8c,12c-trimethyl-8t-methoxycarbonyl-(4arH,8acH)-1,2,4,4a,4b,5,6,7,8,8a,9,10-dodekahydro-3H-2c,10ac-ethano-phenanthren (100353-64-8) → (4ar)-4bt,8c,12c-Trimethyl-8t-methoxycarbonyl-(2tH,4arH,8acH)-1,2,4,4a,4b,5,6,7,8,8a,9,10-dodekahydro-3H-2c,10ac-ethano-phenanthren (30799-71-4,5282-19-9)

Guidance literature:

With hydrogen; nickel;

DOI:10.1021/ja00898a025

upstream raw materials:

kaurenoic acid methyl ester

methyl iodide

(4ar)-2t-Brom-4bt,8c,12c-trimethyl-8t-methoxycarbonyl-(4arH,8acH)-1,2,4,4a,4b,5,6,7,8,8a,9,10-dodekahydro-3H-2c,10ac-ethano-phenanthren

steviol

Refernces

• 1、 Hueso-Falcón, Idaira,Girón, Natalia,Velasco, Pilar,Amaro-Luis, Juan M.,Ravelo, Angel G.,Heras, Beatriz de las,Hortelano, Sonsoles,Estevez-Braun, Ana. "Synthesis and induction of apoptosis signaling pathway of ent-kaurane derivatives". experimental part. p. 1724 - 1735. Retrieved 2010/04/29.