2,2'-difluoro-6,6'-dichlorobibenzyl

Base Information

• Chemical Name: 2,2'-difluoro-6,6'-dichlorobibenzyl
• CAS No.: 170378-95-7
• Molecular Formula: C₁₄H₁₀Cl₂F₂
• Molecular Weight: 287.136
• Mol file: 170378-95-7.mol

Synonyms:

Chemical Property of 2,2'-difluoro-6,6'-dichlorobibenzyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-difluoro-6,6'-dichlorobibenzyl

There total 2 articles about 2,2'-difluoro-6,6'-dichlorobibenzyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(bromomethyl)-1-chloro-3-fluorobenzene (68220-26-8) → 2,2'-difluoro-6,6'-dichlorobibenzyl (170378-95-7)

Guidance literature:

With phenyllithium; In diethyl ether; Yield given;

DOI:10.1016/0022-328X(95)00326-L

Reference yield:

2-chloro-6-fluorotoluene (443-83-4) → 2,2'-difluoro-6,6'-dichlorobibenzyl (170378-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NBS, benzoyl peroxide / CCl₄ / Ambient temperature; Irradiation

2: PhLi / diethyl ether

With N-Bromosuccinimide; Perbenzoic acid; phenyllithium; In tetrachloromethane; diethyl ether;

DOI:10.1016/0022-328X(95)00326-L

Reference yield:

dimethylsilicon dichloride (75-78-5,30107-43-8) + 2,2'-difluoro-6,6'-dichlorobibenzyl (170378-95-7) → 1,2-bis(2-fluorophenyl)ethane (349-38-2) + 1-Chloro-3-fluoro-2-[2-(2-fluoro-phenyl)-ethyl]-benzene + 1,9-difluoro-5,5-dimethyl-10,11-dihydro-5H-dibenzosilepin

Guidance literature:

With magnesium; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, reflux, 1 h, 2.) THF, RT, 4 d;

DOI:10.1016/0022-328X(95)00326-L

upstream raw materials:

2-(bromomethyl)-1-chloro-3-fluorobenzene

2-chloro-6-fluorotoluene

Downstream raw materials:

1,2-bis(2-fluorophenyl)ethane

Refernces

• 1、 Tinnermann, Hendrik,Sung, Simon,Csókás, Dániel,Toh, Zhi Hao,Fraser, Craig,Young, Rowan D.. "Alkali Metal Adducts of an Iron(0) Complex and Their Synergistic FLP-Type Activation of Aliphatic C-X Bonds". supporting information. p. 10700 - 10708. Retrieved 2021/07/31.