349-38-2

Usage

Uses

Used in Pharmaceutical Industry:
1,2-Bis(2-fluorophenyl)ethane is utilized as an intermediate in the synthesis of potential drug candidates. Its unique structure and reactivity make it a valuable component in the development of new pharmaceuticals with diverse therapeutic applications.
Used in Agrochemical Production:
1,2-Bis(2-fluorophenyl)ethane is employed in the production of agrochemicals, where its chemical properties contribute to the creation of effective products for agricultural use. Its versatility in chemical reactions allows for the development of a range of agrochemicals with different functionalities.
Used in Specialty Chemicals:
1,2-Bis(2-fluorophenyl)ethane is also used in the synthesis of specialty chemicals, which are high-value products designed for specific applications. Its unique structure and reactivity enable the production of specialty chemicals with tailored properties to meet the demands of various industries.
Used in Research and Development:
As a research chemical, 1,2-Bis(2-fluorophenyl)ethane is used in academic and industrial laboratories to explore new synthetic pathways and applications. Its unique properties make it an interesting subject for scientific investigation, potentially leading to the discovery of novel compounds and applications.

Upstream product

• 75-78-5 dimethylsilicon dichloride 
• 170378-95-7 2,2'-difluoro-6,6'-dichlorobibenzyl 
• 446-48-0 o-fluorobenzyl bromide 
• 2341-21-1 2-fluoro-N,N-dimethylbenzylamine 
• 17696-23-0 cyclopropanecarboxylic acid dimethylamide 
• 345-35-7 2-fluorobenzyl chloride 
• 149-74-6 dichloromethylphenylsilane 
• 95-52-3 2-Fluorotoluene 

Relevant academic research and scientific papers

Ni-Catalyzed Iterative Alkyl Transfer from Nitrogen Enabled by the in Situ Methylation of Tertiary Amines

Current methods to achieve transition-metal-catalyzed alkyl carbon-nitrogen (C-N) bond cleavage require the preformation of ammonium, pyridinium, or sulfonamide derivatives from the corresponding alkyl amines. These activated substrates permit C-N bond cleavage, and their resultant intermediates can be intercepted to affect carbon-carbon bond-forming transforms. Here, we report the combination of in situ amine methylation and Ni-catalyzed benzalkyl C-N bond cleavage under reductive conditions. This method permits iterative alkyl group transfer from tertiary amines and demonstrates a deaminative strategy for the construction of Csp3-Csp3 bonds. We demonstrate PO(OMe)3 (trimethylphosphate) to be a Ni-compatible methylation reagent for the in situ conversion of trialkyl amines into tetraalkylammonium salts. Single, double, and triple benzalkyl group transfers can all be achieved from the appropriately substituted tertiary amines. Transformations developed herein proceed via recurring events: The in situ methylation of tertiary amines by PO(OMe)3, Ni-catalyzed C-N bond cleavage, and concurrent Csp3-Csp3 bond formation.

An unprecedented oxidative intermolecular homo coupling reaction between two sp3C–sp3C centers under metal-free condition

An unprecedented formation of benzylic sp3C–sp3C coupled dibenzylic products has been illustrated. The reactions have been carried out in the presence of three oxidizing reagents, i.e., diacetoxy-iodobenzene (IBDA), N-fluorobenzenesulfonimide (NFSI), and pyridine (Py) using toluene derivatives.

IMPROVED PROCESS FOR THE PREPARATION OF PRASUGREL AND INTERMEDIATE THEREOF

The invention relates to an industrial scale process for the preparation of l-cyclopropyl-2-(2- fluorophenyl)-ethanone of the Formula (1) and the use of this compound for the preparation of prasugrel.

Homo- and hetero-oxidative coupling of benzyl anions

The regioselective benzylic metalation of substituted toluenes using BuLi/KO-t-Bu/TMP(H) (LiNK metalation conditions) with subsequent in situ oxidative C-C coupling has been developed for the facile generation of 1,2-diarylethanes. A range of oxidants can be used for the oxidative coupling step, with 1,2-dibromoethane proving optimal. Heterocouplings can be achieved starting from a mixture of two different toluenes with a bias toward cross coupling achievable by using a 2-fold excess of one toluene starting material. The utility of this approach is illustrated by the synthesis of several biologically active natural products. A distinct advantage is that the synthetic steps typically required to preactivate the coupling substrates are eliminated and no transition metal is required to facilitate the C-C bond formation.

Flash vacuum pyrolysis over magnesium. Part 1 - Pyrolysis of benzylic, other aryl/alkyl and aliphatic halides

Flash vacuum pyrolysis over a bed of freshly sublimed magnesium on glass wool results in efficient coupling of benzyl halides to give the corresponding bibenzyls. Where an ortho halogen substituent is present further dehalogenation gives some dihydroanthracene and anthracene. Efficient coupling is also observed for halomethylnaphthalenes and halodiphenylmethanes while chlorotriphenylmethane gives 4,4′-bis(diphenylmethyl)biphenyl. By using α,α′-dihalo-o-xylenes, benzocyclobutenes are obtained in good yield, while the isomeric α,α′-dihalo-p-xylenes give a range of high thermal stability polymers by polymerisation of the initially formed p-xylylenes. Other haloalkylbenzenes undergo largely dehydrohalogenation where this is possible, in some cases resulting in cyclisation. Deoxygenation is also observed with haloalkyl phenyl ketones to give phenylalkynes as well as other products. With simple alkyl halides there is efficient elimination of HCl or HBr to give alkenes. For aliphatic dihalides this also occurs to give dienes but there is also cyclisation to give cycloalkanes and dehalogenation with hydrogen atom transfer to give alkenes in some cases. For 5-bromopent-1-ene the products are those expected from a radical pathway but for 6-bromohex-1-ene they are clearly not. For 2,2-dichloropropane and 1,1-dichloropropane elimination of HCl occurs but for 1,1-dichlorobutane, -pentane and -hexane partial hydrolysis followed by elimination of HCl gives E, E-, E,Z- and Z,Z- isomers of the dialk-1-enyl ethers and fully assigned 13C NMR data are presented for these. With 6-chlorohex-1-yne and 7-chlorohept-1-yne there is cyclisation to give methylenecycloalkanes and -cycloalkynes. The behaviour of 1,2-dibromocyclohexane and 1,2-dichlorocyclooctane under these conditions is also examined. Various pieces of evidence are presented that suggest that these processes do not involve generation of free gas-phase radicals but rather surface-adsorbed organometallic species.

Dehalogenation of organic halides by flash vacuum pyrolysis over magnesium: A versatile synthetic method

Flash vacuum pyrolysis over magnesium at 600°C results in efficient dehalogenation of a variety of organic halides and provides a preparatively useful method for C-C bond formation and other reactions.

Synthesis and characterization of 1,9-difluoro-5-methyl-5-phenyl-10,11-dihydro-5H-dibenzosilepin

The synthesis of 2,2'-difluoro-6,6'-dichlorobibenzyl, a precursor to dibenzometallepins, has been accomplished from bromination of 2-chloro-6-toluene followed by coupling of the benzyl bromide produced with PhLi.A variety of conditions were studied for co