(1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: (1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
• CAS No.: 188258-35-7
• Molecular Formula: C₂₉H₃₃FO₄
• Molecular Weight: 464.577
• Mol file: 188258-35-7.mol

Synonyms:

Chemical Property of (1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

There total 4 articles about (1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[(3,5-Dimethyl-phenyl)-fluoro-methyl]-phosphonic acid diethyl ester (188258-30-2) → (1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester (188258-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / KN(TMS)2 / tetrahydrofuran

2: LiOH / tetrahydrofuran; H₂O

3: 1.) 1-chloro-N,N,2-trimethylpropenylamine, 2.) Et₃N

With lithium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; water;

DOI:10.1016/S0960-894X(96)00624-5

Reference yield:

3-Benzyl-4-oxo-cyclohexanecarboxylic acid ethyl ester → (1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester (188258-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / KN(TMS)2 / tetrahydrofuran

2: LiOH / tetrahydrofuran; H₂O

3: 1.) 1-chloro-N,N,2-trimethylpropenylamine, 2.) Et₃N

With lithium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; water;

DOI:10.1016/S0960-894X(96)00624-5

Reference yield:

(1S,3S)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid ethyl ester → (1R,3R)-3-Benzyl-4-[1-(3,5-dimethyl-phenyl)-1-fluoro-meth-(Z)-ylidene]-cyclohexanecarboxylic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester (188258-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiOH / tetrahydrofuran; H₂O

2: 1.) 1-chloro-N,N,2-trimethylpropenylamine, 2.) Et₃N

With lithium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; triethylamine; In tetrahydrofuran; water;

DOI:10.1016/S0960-894X(96)00624-5

upstream raw materials:

(R)-Pantolacton

[(3,5-Dimethyl-phenyl)-fluoro-methyl]-phosphonic acid diethyl ester