3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole

Base Information

Chemical Name:3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole
CAS No.:1270943-11-7
Molecular Formula:C₂₃H₁₉ClN₂O
Molecular Weight:374.87
Hs Code.:

Synonyms:

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Chemical Property of 3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole

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Technology Process of 3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole

There total 4 articles about 3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 1270943-11-7
3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: acetic acid / tetrahydrofuran; tert-butyl alcohol / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere

3: N-Bromosuccinimide / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triphenylphosphine / tetrahydrofuran; water; tert-butyl alcohol / 0.33 h / 160 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; water; tert-butyl alcohol; 1: Sonogashira coupling / 4: Suzuki coupling;
DOI:10.1021/ol2004947

Reference yield:

: 536-74-3
phenylacetylene

: 1270943-11-7
3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: acetic acid / tetrahydrofuran; tert-butyl alcohol / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere

3: N-Bromosuccinimide / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Inert atmosphere

4: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triphenylphosphine / tetrahydrofuran; water; tert-butyl alcohol / 0.33 h / 160 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; water; tert-butyl alcohol; 1: Sonogashira coupling / 4: Suzuki coupling;
DOI:10.1021/ol2004947

Reference yield:

: 16616-42-5
p-chlorobenzoylphenylacetylene

: 1270943-11-7
3-(4-chlorophenyl)-4-(4-methoxyphenyl)-1-methyl-5-phenyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / tetrahydrofuran; tert-butyl alcohol / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere

2: N-Bromosuccinimide / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; triphenylphosphine / tetrahydrofuran; water; tert-butyl alcohol / 0.33 h / 160 °C / Microwave irradiation; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; potassium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; water; tert-butyl alcohol; 3: Suzuki coupling;
DOI:10.1021/ol2004947