Methyl 2-bromo-3-methoxybenzeneacetate

Base Information

• Chemical Name: Methyl 2-bromo-3-methoxybenzeneacetate
• CAS No.: 128828-88-6
• Molecular Formula: C₁₀H₁₁BrO₃
• Molecular Weight: 259.1
• DSSTox Substance ID: DTXSID501283145
• Mol file: 128828-88-6.mol

Synonyms:Methyl 2-bromo-3-methoxybenzeneacetate;DTXSID501283145;128828-88-6

Chemical Property of Methyl 2-bromo-3-methoxybenzeneacetate

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 257.98916
• Heavy Atom Count: 14
• Complexity: 196

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1Br)CC(=O)OC

Technology Process of Methyl 2-bromo-3-methoxybenzeneacetate

There total 4 articles about Methyl 2-bromo-3-methoxybenzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-bromo-3-methoxyphenyl)acetonitrile (128828-87-5) → methyl (2-bromo-3-methoxyphenyl)acetate (128828-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 6M sodium hydroxide / methanol / 12 h / Ambient temperature

2: diethyl ether / 1 h / 0 °C

With sodium hydroxide; In methanol; diethyl ether;

DOI:10.1016/S0040-4020(01)80642-6

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (2-bromo-3-methoxyphenyl)acetic acid (54639-89-3) → methyl (2-bromo-3-methoxyphenyl)acetate (128828-88-6)

Guidance literature:

In diethyl ether; Yield given; Ambient temperature;

DOI:10.1016/S0040-4039(00)70714-3

Reference yield:

2-bromo-3-methylanisole (38197-43-2) → methyl (2-bromo-3-methoxyphenyl)acetate (128828-88-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Br₂ / CCl₄ / Ambient temperature; Irradiation

2: dimethylsulfoxide / Ambient temperature

3: KOH / methanol / Heating

4: diethyl ether / Ambient temperature

With potassium hydroxide; bromine; In methanol; tetrachloromethane; diethyl ether; dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)70714-3

upstream raw materials:

diazomethane

(2-bromo-3-methoxyphenyl)acetic acid

(2-bromo-3-methoxyphenyl)acetonitrile

2-bromo-3-methylanisole

Downstream raw materials:

methyl 7-benzy loxy-2-(2-bromo-3-methoxyphenyl)-3-hydroxyheptanoate

6-benzyloxy-1-(2-bromo-3-methoxyphenyl)-2-hexanone

methyl 7-benzyloxy-2-(2-bromo-3-methoxyphenyl)-3-oxoheptanoate

(E)-6-benzyloxy-1-(2-bromo-3-methoxyphenyl)-2-methoxy-1-hexene