Boc-PheΨSta-Leu-NHCH2Ph

Base Information

• Chemical Name: Boc-PheΨSta-Leu-NHCH2Ph
• CAS No.: 118404-99-2
• Molecular Formula: C₃₈H₅₆N₄O₇
• Molecular Weight: 680.885
• Mol file: 118404-99-2.mol

Synonyms:

Chemical Property of Boc-PheΨSta-Leu-NHCH2Ph

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-PheΨSta-Leu-NHCH2Ph

There total 4 articles about Boc-PheΨSta-Leu-NHCH2Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E,4R,S,5S)-5-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-6-phenyl-2-hexenoic acid (99113-32-3,99113-34-5,118386-98-4) → Boc-PheΨSta-Leu-NHCH2Ph (118404-99-2,124338-96-1,124339-24-8)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1.) 0 deg C, 0.5 h, 2.) room temp., overnight;

DOI:10.1021/jm00164a058

Reference yield:

Methyl (S)-5-<(tert-butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoate (118457-05-9) → Boc-PheΨSta-Leu-NHCH2Ph (118404-99-2,124338-96-1,124339-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 72 h / Ambient temperature

2: 1.1 g / 1 N NaOH / methanol / 2 h / Ambient temperature

3: 325 mg / HOBT/DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) room temp., overnight

With sodium hydroxide; benzotriazol-1-ol; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a058

Reference yield:

[3-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-oxiranyl]-acetic acid methyl ester (124266-92-8,124339-16-8) → Boc-PheΨSta-Leu-NHCH2Ph (118404-99-2,124338-96-1,124339-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.1 g / 1 N NaOH / methanol / 2 h / Ambient temperature

2: 325 mg / HOBT/DCC, Et₃N / dimethylformamide / 1.) 0 deg C, 0.5 h, 2.) room temp., overnight

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00164a058

upstream raw materials:

(2E,4R,S,5S)-5-<<(1,1-dimethylethoxy)carbonyl>amino>-4-hydroxy-6-phenyl-2-hexenoic acid

Methyl (S)-5-<(tert-butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoate

[3-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-oxiranyl]-acetic acid methyl ester

(E)-(S)-<1-(phenylmethyl)-5-(trimethylsilyl)-3-hexen-5-ynyl>carbamic acid 1,1-dimethylethyl ester

Downstream raw materials:

Boc-PheΨSta-Leu-NHCH2Ph

Boc-PheΨGly-Sta-Leu-NHCH2Ph