hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester

Base Information

• Chemical Name: hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester
• CAS No.: 592508-47-9
• Molecular Formula: C₂₈H₃₂O₆
• Molecular Weight: 464.558
• Mol file: 592508-47-9.mol

Synonyms:

Chemical Property of hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester

There total 8 articles about hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-cresol (106-44-5) → hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester (592508-47-9)

Guidance literature:

Multi-step reaction with 6 steps

1: K₂CO₃ / N,N-dimethyl-acetamide / Heating

2: mCPBA

3: K₂CO₃ / acetone

4: 1,2-dichloro-benzene / Heating

5: H₂ / Pd/C

6: Cs₂CO₃ / dimethylformamide / 65 °C

With hydrogen; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; 2: Baeyer-Villiger oxidation / 4: Claisen rearrangement;

DOI:10.1016/S0960-894X(03)00257-9

Reference yield:

4-(p-tolyloxy)phenol (35094-91-8) → hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester (592508-47-9)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / acetone

2: 1,2-dichloro-benzene / Heating

3: H₂ / Pd/C

4: Cs₂CO₃ / dimethylformamide / 65 °C

With hydrogen; potassium carbonate; caesium carbonate; palladium on activated charcoal; In N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; 2: Claisen rearrangement;

DOI:10.1016/S0960-894X(03)00257-9

Reference yield:

4-fluorobenzaldehyde (459-57-4) → hydroxy-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-acetic acid methyl ester (592508-47-9)

Guidance literature:

Multi-step reaction with 6 steps

1: K₂CO₃ / N,N-dimethyl-acetamide / Heating

2: mCPBA

3: K₂CO₃ / acetone

4: 1,2-dichloro-benzene / Heating

5: H₂ / Pd/C

6: Cs₂CO₃ / dimethylformamide / 65 °C

With hydrogen; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In N,N-dimethyl acetamide; N,N-dimethyl-formamide; 1,2-dichloro-benzene; acetone; 2: Baeyer-Villiger oxidation / 4: Claisen rearrangement;

DOI:10.1016/S0960-894X(03)00257-9

upstream raw materials:

[4-(3-bromo-propoxy)-phenyl]-hydroxy-acetic acid methyl ester

2-Propyl-4-(4'-methylphenoxy)phenol

p-cresol

4-(p-tolyloxy)phenol

Downstream raw materials:

2-imino-5-{4-[3-(2-propyl-4-p-tolyloxy-phenoxy)-propoxy]-phenyl}-thiazolidin-4-one