C₃₆H₄₄F₂N₄O₄

Base Information

Chemical Name:C₃₆H₄₄F₂N₄O₄
CAS No.:1345705-79-4
Molecular Formula:C₃₆H₄₄F₂N₄O₄
Molecular Weight:634.767
Hs Code.:

C<sub>36</sub>H<sub>44</sub>F<sub>2</sub>N<sub>4</sub>O<sub>4</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₃₆H₄₄F₂N₄O₄

Chemical Property:

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Technology Process of C₃₆H₄₄F₂N₄O₄

There total 21 articles about C₃₆H₄₄F₂N₄O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 877078-49-4
(S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one

: 1345705-79-4
C₃₆H₄₄F₂N₄O₄

Guidance literature:: Multi-step reaction with 12 steps

1.1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

2.1: 2,6-dimethylpyridine / dichloromethane

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water

4.1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / toluene / 75 °C

5.1: 75 °C

6.1: Wilkinson's catalyst / ethanol; water / Reflux

6.2: 20 °C / pH 10 / aq. buffer

7.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

8.1: methanol; potassium carbonate / 20 °C

9.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

10.1: palladium on activated charcoal; hydrogen / methanol

11.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

12.1: hydrogenchloride / 1,4-dioxane; water

With 4-methyl-morpholine; 2,6-dimethylpyridine; hydrogenchloride; methanol; Wilkinson's catalyst; di-n-butylboryl trifluoromethanesulfonate; diphenyl phosphoryl azide; palladium on activated charcoal; HATU; hydrogen; dihydrogen peroxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4.1: Curtius rearrangement / 7.1: Mitsunobu reaction / 9.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.06.109

Reference yield:

: 910447-90-4
(2R,4R)-tert-butyl 2-((1S,2S)-2-(benzyloxycarbonylamino)-1-(tert-butyldimethylsilyloxy)-3-(3,5-difluorophenyl)propyl)-4-hydroxypyrrolidine-1-carboxylate

: 1345705-79-4
C₃₆H₄₄F₂N₄O₄

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

2: methanol; potassium carbonate / 20 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 20 °C

4: palladium on activated charcoal; hydrogen / methanol

5: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

6: hydrogenchloride / 1,4-dioxane; water

With 4-methyl-morpholine; hydrogenchloride; methanol; palladium on activated charcoal; HATU; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; 1: Mitsunobu reaction / 3: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2011.06.109

Reference yield:

: 1345706-85-5
C₂₀H₂₉NO₃

: 1345705-79-4
C₃₆H₄₄F₂N₄O₄

Guidance literature:: Multi-step reaction with 5 steps

1: ozone / methanol

2: triethylsilane; trifluoroacetic acid / dichloromethane / 0 °C

3: lithium hydroxide / tetrahydrofuran / 20 °C

4: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide

5: hydrogenchloride / 1,4-dioxane; water

With 4-methyl-morpholine; hydrogenchloride; triethylsilane; HATU; ozone; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.06.109