(S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid

Base Information

Chemical Name:(S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid
CAS No.:727426-58-6
Molecular Formula:C₄₃H₆₃N₅O₁₀
Molecular Weight:810.001
Hs Code.:

(S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid

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Chemical Property of (S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid

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Technology Process of (S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid

There total 8 articles about (S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-33-3
N-benzyloxyamine

: 727426-58-6
(S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: DIEA / methanol

2: trifluoroacetic acid

3: acylase

4: Et₃N

5: DCC; DMAP

6: trifluoroacetic acid

7: HBTU; HOBt*H₂O; Et₃N

8: TBAF / tetrahydrofuran

With dmap; acylase; tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

: 669091-27-4
2-(N-acetylamino)-8-bromooctanoic acid

: 727426-58-6
(S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: DMAP

2: DIEA / methanol

3: trifluoroacetic acid

4: acylase

5: Et₃N

6: DCC; DMAP

7: trifluoroacetic acid

8: HBTU; HOBt*H₂O; Et₃N

9: TBAF / tetrahydrofuran

With dmap; acylase; tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.03.018

Reference yield:

: 727426-15-5
2-acetylamino-8-bromo-octanoic acid tert-butyl ester

: 727426-58-6
(S)-8-(Benzyloxy-formyl-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-octanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: DIEA / methanol

2: trifluoroacetic acid

3: acylase

4: Et₃N

5: DCC; DMAP

6: trifluoroacetic acid

7: HBTU; HOBt*H₂O; Et₃N

8: TBAF / tetrahydrofuran

With dmap; acylase; tetrabutyl ammonium fluoride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.03.018