Technology Process of C17H11F4N5
There total 12 articles about C17H11F4N5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine;
In
ethanol;
at 20 - 60 ℃;
for 96h;
In
dichloromethane;
at 20 ℃;
With
trichlorophosphate;
In
dichloromethane; toluene;
at 65 ℃;
for 0.5h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: isopropyl alcohol / 50 °C
2: caesium carbonate / tetrahydrofuran; isopropyl alcohol
3: hydrogenchloride / water
4: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 75 °C
5: ammonium acetate; ammonium hydroxide; zinc / ethanol; water / 80 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane
7: trichlorophosphate / 100 °C
8: ammonia / methanol
9: trifluoroacetic anhydride / tetrahydrofuran; pyridine
10: hydrazine hydrate / methanol
11: 120 °C
With
hydrogenchloride; hydroxylamine hydrochloride; ammonium acetate; ammonia; caesium carbonate; ammonium hydroxide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; zinc; trichlorophosphate;
In
tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; water; isopropyl alcohol;
2: Horner-Emmons condensation;
DOI:10.1016/j.bmcl.2011.08.071
- Guidance literature:
-
Multi-step reaction with 3 steps
1: trifluoroacetic anhydride / tetrahydrofuran; pyridine
2: hydrazine hydrate / methanol
3: 120 °C
With
hydrazine hydrate; trifluoroacetic anhydride;
In
tetrahydrofuran; pyridine; methanol;
DOI:10.1016/j.bmcl.2011.08.071
