Technology Process of C27H38N2O4
There total 5 articles about C27H38N2O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-4-benzyl-N-(5-hexynoyl)-5,5-dimethyl-1,3-oxazolidin-2-one;
With
titanium tetrachloride; triethylamine;
In
dichloromethane;
at 23 ℃;
for 0.75h;
2,2,6,6-tetramethyl-piperidine-N-oxyl;
In
dichloromethane;
at 23 ℃;
for 2h;
Overall yield = 73 %; Overall yield = 0.11 g; diastereoselective reaction;
DOI:10.1021/ol403398u
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; zinc / tetrahydrofuran / 2 h / 50 °C
2.1: methanol / dichloromethane; diethyl ether / 0.08 h / 0 °C
3.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere
3.2: 18 h / 23 °C / Inert atmosphere
4.1: triethylamine; titanium tetrachloride / dichloromethane / 0.75 h / 23 °C
4.2: 2 h / 23 °C
With
methanol; pivaloyl chloride; titanium tetrachloride; acetic acid; triethylamine; zinc;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol403398u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanol / dichloromethane; diethyl ether / 0.08 h / 0 °C
2.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 0.5 h / -30 °C / Inert atmosphere
2.2: 18 h / 23 °C / Inert atmosphere
3.1: triethylamine; titanium tetrachloride / dichloromethane / 0.75 h / 23 °C
3.2: 2 h / 23 °C
With
methanol; pivaloyl chloride; titanium tetrachloride; triethylamine;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol403398u
