[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt

Base Information

Chemical Name:[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt
CAS No.:1079989-95-9
Molecular Formula:C₆H₁₄N₂O₂*C₂₀H₁₅ClFN₅O₅S₂
Molecular Weight:670.142
Hs Code.:

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Chemical Property of [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt

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Technology Process of [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt

There total 9 articles about [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 936500-94-6
Elinogrel

: 56-87-1,3506-25-0
L-lysine

: 1079989-95-9
[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt

Guidance literature:: In isopropyl alcohol; for 2h;

Reference yield:

: 207346-42-7
2-amino-4,5-difluoro-benzoic acid,methyl ester

: 1079989-95-9
[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 3 h / 40 °C

2.1: triethylamine / tetrahydrofuran / 0.42 h

2.2: 2 h / 65 °C

3.1: methanol; sodium methylate / tetrahydrofuran / 4.33 h / 25 - 30 °C

4.1: hydrogenchloride / 1,4-dioxane / 5 - 6 h / 20 - 30 °C

5.1: ethanol; dimethyl sulfoxide / 5.67 h / 25 - 110 °C

6.1: dimethyl sulfoxide / 15 h / 65 °C

7.1: isopropyl alcohol / 2 h

With hydrogenchloride; methanol; sodium methylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: C₉H₅F₂NO₃

: 1079989-95-9
[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: methanol; sodium methylate / tetrahydrofuran / 4.33 h / 25 - 30 °C

3: hydrogenchloride / 1,4-dioxane / 5 - 6 h / 20 - 30 °C

4: ethanol; dimethyl sulfoxide / 5.67 h / 25 - 110 °C

5: dimethyl sulfoxide / 15 h / 65 °C

6: isopropyl alcohol / 2 h

With hydrogenchloride; methanol; sodium methylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;