207346-42-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-amino-4,5-difluorobenzoate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel drugs. The presence of fluorine atoms can enhance the pharmacokinetic properties of the resulting compounds, potentially improving their efficacy and safety.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 2-amino-4,5-difluorobenzoate is utilized as a precursor in the production of agrochemicals. Its unique structure allows for the creation of compounds that can be effective in pest and disease control, taking advantage of the reactive nature of the fluorine atoms and the functional groups present in the molecule.
Used in Organic Synthesis:
Methyl 2-amino-4,5-difluorobenzoate serves as a versatile intermediate in organic synthesis, where its structural features can be exploited to produce a variety of organic compounds. The amino group on the benzene ring is particularly useful for further functionalization, making it a valuable building block for the synthesis of complex organic molecules.

InChI:InChI=1/C8H7F2NO2/c1-13-8(12)4-2-5(9)6(10)3-7(4)11/h2-3H,11H2,1H3

Upstream product

• 67-56-1 methanol 
• 83506-93-8 2-amino-4,5-difluorobenzoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1015433-96-1 methyl 4,5-difluoro-2-nitrobenzoate 

Downstream Products

• 1255091-97-4 C₁₆H₁₀F₂N₂O₄ 
• 1015433-98-3 C₁₇H₁₄F₂N₂O₅ 
• 936500-97-9 C₉H₆ClF₂NO₃ 
• 207346-43-8 C₁₅H₁₀F₂N₂O₆ 
• 1352126-81-8 2-[2-(2-fluorobenzoylamino)-benzoylamino]-4,5-difluorobenzoic acid 
• 864292-99-9 methyl 2-amino-5-fluoro-4-methoxybenzoate 
• 1079989-99-3 [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea N-ethylglucamine salt 
• 1079989-95-9 [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea L-lysine salt 
• 1079989-98-2 [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt 

Relevant academic research and scientific papers

ANTIVIRAL COMPOUNDS

The present invention provides new antiviral compounds and pharmacological compositions comprising these new compounds and their use in the prophylaxis, prevention and treatment of viral infections, particularly adenovirus and herpes virus infections.

Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication

2-[2-Benzoylamino)benzoylamino]benzoic acid (1) was previously identified as a potent and nontoxic antiadenoviral compound (Antimicrob. Agents Chemother. 2010, 54, 3871). Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds and that the direction of the amide bonds (as in 1) is obligatory. Some variability in the N-terminal moiety was tolerated, but benzamides appear to be preferred. The substituents on the middle and C-terminal rings were varied, resulting in two potent inhibitors, 35g and 35j, with EC50 = 0.6 μM and low cell toxicity.

NEW ANTIVIRAL COMPOUNDS

The present invention provides new antiviral compounds and pharmacological compositions comprising these new compounds and their use in the prophylaxis, prevention and treatment of viral infections, particularly adenovirus and herpes virus infections.

PLATELET ADP RECEPTOR INHIBITORS

Compounds are provided which are useful as platelet ADP receptor inhibitors, for treating thrombosis and for reducing the likelihood and/or severity of a secondary ischemic event in a patient.

4-Hydroxy-2-quinolones. 90.* Synthesis and antitubercular activity of 4-methyl-2-thiazolylamides of halo-substituted 4-hydroxy-2-oxo-1,2-dihydro-3- quinolinecarboxylic acids

Several variants were studied for the synthesis of esters of halogen derivatives of 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic acids, whose reaction with 2-amino-4-methylthiazole gives the corresponding hetarylamides. Results are given for a study of the antitubercular activity of these products. 2006 Springer Science+Business Media, Inc.

Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones

The invention provides chemistry libraries containing fused 2,4-pyrimidinediones. The invention also provides methods for the construction of fused 2,4-pyrimidinedione containing libraries. The invention further provides methods for the identification of