5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide

Base Information

Chemical Name:5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide
CAS No.:1437050-72-0
Molecular Formula:C₃₀H₂₅BCl₂F₃N₃O₄
Molecular Weight:630.258
Hs Code.:

5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide

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Chemical Property of 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide

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Technology Process of 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide

There total 8 articles about 5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1437051-74-5
3,3-dimethyl-6-((methylamino)methyl)benzo[c][1,2]oxaborol-1(3H)-ol

: C₁₁H₁₆BNO₂*ClH

: 1437050-72-0
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide

Guidance literature:: With triethylamine; HATU;

Reference yield:

: 1437051-71-2
1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbaldehyde

: 1437050-72-0
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / pH 6

2: HATU; triethylamine

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; HATU; In tetrahydrofuran;

Reference yield:

: 1437053-60-5
2-bromo-1-(2-(ethoxymethoxy)propan-2-yl)-4-methylbenzene

: 1437050-72-0
5-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)methyl)-N-methylindolizine-8-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

2: hydrogenchloride / tetrahydrofuran / 20 °C

3: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / 20 °C / Reflux

4: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 20 °C / pH 6

5: HATU; triethylamine

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; potassium acetate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; HATU; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane;