Acetamide, N-(4-((5-((4-methylphenyl)amino)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)-

Base Information

• Chemical Name: Acetamide, N-(4-((5-((4-methylphenyl)amino)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)-
• CAS No.: 151392-13-1
• Molecular Formula: C₁₈H₁₈N₄O₃
• Molecular Weight: 338.366
• DSSTox Substance ID: DTXSID90164781
• Nikkaji Number: J578.289I
• Wikidata: Q83033858
• Mol file: 151392-13-1.mol

Synonyms:N-(4-((5-((4-Methylphenyl)amino)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)acetamide;Acetamide, N-(4-((5-((4-methylphenyl)amino)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)-;151392-13-1;N-[4-[[5-[(4-Methylphenyl)amino]-1,3,4-oxadiazol-2-yl]methoxy]phenyl]acetamide;DTXSID90164781;LS-9945

Chemical Property of Acetamide, N-(4-((5-((4-methylphenyl)amino)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)-

Chemical Property:

• Density: 1.307g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 338.13789045
• Heavy Atom Count: 25
• Complexity: 421

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC2=NN=C(O2)COC3=CC=C(C=C3)NC(=O)C

Technology Process of Acetamide, N-(4-((5-((4-methylphenyl)amino)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)-

There total 4 articles about Acetamide, N-(4-((5-((4-methylphenyl)amino)-1,3,4-oxadiazol-2-yl)methoxy)phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.8%

N1-<(acetamidophen-4-yl)oxy>acetyl-N4-(4-methylphenyl)-3-thiosemicarbazide (151392-09-5) → 5-<(acetamidophen-4-yl)oxy>methyl-2-(4-methylphenyl)amino-1,3,4-oxadiazole (151392-13-1)

Guidance literature:

With sodium hydroxide; iodine; potassium iodide; In ethanol; water; Ambient temperature;

DOI:10.1002/jps.2600830226

Reference yield:

ethyl 2-[4-(acetylamino)phenoxy]acetate (67202-81-7) → 5-<(acetamidophen-4-yl)oxy>methyl-2-(4-methylphenyl)amino-1,3,4-oxadiazole (151392-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 67.2 percent / 99percent hydrazine hydrate / ethanol / 2 h / Heating

2: 83.3 percent / ethanol / 4 h / Heating

3: 17.8 percent / 2N NaOH, I₂, 5percent KI / ethanol; H₂O / Ambient temperature

With sodium hydroxide; iodine; hydrazine hydrate; potassium iodide; In ethanol; water;

DOI:10.1002/jps.2600830226

Reference yield:

N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide (75129-75-8) → 5-<(acetamidophen-4-yl)oxy>methyl-2-(4-methylphenyl)amino-1,3,4-oxadiazole (151392-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 83.3 percent / ethanol / 4 h / Heating

2: 17.8 percent / 2N NaOH, I₂, 5percent KI / ethanol; H₂O / Ambient temperature

With sodium hydroxide; iodine; potassium iodide; In ethanol; water;

DOI:10.1002/jps.2600830226

upstream raw materials:

N¹-<(acetamidophen-4-yl)oxy>acetyl-N⁴-(4-methylphenyl)-3-thiosemicarbazide

4-acetaminophenol

ethyl 2-[4-(acetylamino)phenoxy]acetate

N‐(4‐(2‐hydrazinyl‐2‐oxoethoxy)phenyl) acetamide