4-(ACETYLAMINO)PHENOXYACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: 4-(ACETYLAMINO)PHENOXYACETIC ACID ETHYL ESTER
• CAS No.: 67202-81-7
• Molecular Formula: C12H15 N O4
• Molecular Weight: 237.255
• Mol file: 67202-81-7.mol

Synonyms:Aceticacid, (p-acetamidophenoxy)-, ethyl ester (7CI);Acetic acid, [4-(acetylamino)phenoxy]-,ethyl ester (9CI); NSC 212161

Chemical Property of 4-(ACETYLAMINO)PHENOXYACETIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.76E-07mmHg at 25°C
• Boiling Point: 416.6°Cat760mmHg
• Flash Point: 205.8°C
• PSA: 64.63000
• Density: 1.189g/cm³
• LogP: 1.65990

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(4-acetamidophenoxy)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(ACETYLAMINO)PHENOXYACETIC ACID ETHYL ESTER

There total 3 articles about 4-(ACETYLAMINO)PHENOXYACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-acetaminophenol (103-90-2,8055-08-1) + ethyl bromoacetate (105-36-2) → ethyl 2-[4-(acetylamino)phenoxy]acetate (67202-81-7)

Guidance literature:

With potassium carbonate; at 70 ℃; for 16h;

DOI:10.1080/00397911.2015.1041048

Reference yield: 38.0%

4-acetaminophenol (103-90-2,8055-08-1) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-[4-(acetylamino)phenoxy]acetate (67202-81-7)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Heating;

Reference yield:

→ ethyl 2-[4-(acetylamino)phenoxy]acetate (67202-81-7)

Guidance literature:

/BRN= 3322816/;

upstream raw materials:

4-acetaminophenol

chloroacetic acid ethyl ester

ethyl bromoacetate

Downstream raw materials:

N-{4-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methoxy]phenyl}acetamide

C₂₂H₁₇N₃O₆S

4-aminophenoxyacetic acid

Refernces

• 1、 -. "PRMT5 INHIBITORS AND USES THEREOF". Paragraph 0277-0278. . Retrieved 2019/04/05.
• 2、 Morar, Cristina,Cost, Lavinia,Lameiras, Pedro,Antheaume, Cyril,Darabantu, Mircea. "Convergent Versus Divergent Three-Step Synthesis of the First (4-Aminophenoxy)alkanoic Acid-Based Tripodal Melamines". supporting information. p. 1688 - 1695. Retrieved 2015/06/25.