2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol

Base Information

• Chemical Name: 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol
• CAS No.: 394-58-1
• Molecular Formula: C₈H₆Cl₂F₂O
• Molecular Weight: 227.038
• Mol file: 394-58-1.mol

Synonyms:

Chemical Property of 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol

There total 5 articles about 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-1-(4-chloro-phenyl)-2,2-difluoro-ethanone (774-29-8) → 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol (394-58-1)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01572a051

Reference yield:

(4-chlorphenyl)magnesium bromide (873-77-8) → 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol (394-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: LiAlH₄; diethyl ether

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01572a051

Reference yield:

C11H14Cl2F2OSi → 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol (394-58-1)

Guidance literature:

With trifluoroacetic acid; In ethanol; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c8cc09115c

upstream raw materials:

2-chloro-1-(4-chloro-phenyl)-2,2-difluoro-ethanone

(4-chlorphenyl)magnesium bromide

4-chlorobenzaldehyde