2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanone

Base Information

• Chemical Name: 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanone
• CAS No.: 774-29-8
• Molecular Formula: C8H4Cl2F2O
• Molecular Weight: 225.022
• Mol file: 774-29-8.mol

Synonyms:NSC 42610;

Chemical Property of 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanone

Chemical Property:

• Vapor Pressure: 0.0208mmHg at 25°C
• Refractive Index: 1.508
• Boiling Point: 251.2 °C at 760 mmHg
• Flash Point: 105.7 °C
• Density: 1.449 g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanone

There total 1 articles about 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chlorphenyl)magnesium bromide (873-77-8) + 2-chloro-2,2-difluoroacetic acid (76-04-0) → 2-chloro-1-(4-chloro-phenyl)-2,2-difluoro-ethanone (774-29-8)

Guidance literature:

With diethyl ether;

DOI:10.1021/ja01572a051

Reference yield: 66.0%

2-chloro-1-(4-chloro-phenyl)-2,2-difluoro-ethanone (774-29-8) + [chloro(difluoro)methyl]trimethylsilane (115262-00-5) → 1-chloro-4-(3-chloro-1,1,3,3-tetrafluoroprop-1-en-2-yl)benzene

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 80 ℃; for 10h; Sealed tube;

DOI:10.3762/bjoc.10.32

Reference yield:

2-chloro-1-(4-chloro-phenyl)-2,2-difluoro-ethanone (774-29-8) → 2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol (394-58-1)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/ja01572a051

upstream raw materials:

(4-chlorphenyl)magnesium bromide

2-chloro-2,2-difluoroacetic acid

Downstream raw materials:

2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanol

2-chloro-1,1-bis-(4-chloro-phenyl)-2,2-difluoro-ethanol

4-(difluoromethoxy)-1,1′-biphenyl