Technology Process of 3-[(2,4-difluorophenyl)amino]-8-(2-morpholin-4-ylethoxy)-dibenzo[b,e]oxepin-11(6H)-one
There total 8 articles about 3-[(2,4-difluorophenyl)amino]-8-(2-morpholin-4-ylethoxy)-dibenzo[b,e]oxepin-11(6H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; XPhos;
In
1,4-dioxane; tert-butyl alcohol;
at 110 ℃;
for 6h;
Inert atmosphere;
DOI:10.1021/jm401276h
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 72 °C
2.1: potassium carbonate / acetone / 4 h / Reflux
3.1: potassium hydroxide / water; methanol / 4 h / 40 °C
4.1: trifluoroacetic anhydride; thionyl chloride / dichloromethane / 0.5 h / 20 °C
4.2: 1.5 h
5.1: boron tribromide / dichloromethane / -20 °C / Inert atmosphere
6.1: potassium carbonate / acetone / 6 h / Reflux; Inert atmosphere
7.1: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane; tert-butyl alcohol / 6 h / 110 °C / Inert atmosphere
With
N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); palladium diacetate; boron tribromide; potassium carbonate; caesium carbonate; trifluoroacetic anhydride; potassium hydroxide; XPhos;
In
1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jm401276h
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid / water / 6 h / Reflux
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 72 °C
3.1: potassium carbonate / acetone / 4 h / Reflux
4.1: potassium hydroxide / water; methanol / 4 h / 40 °C
5.1: trifluoroacetic anhydride; thionyl chloride / dichloromethane / 0.5 h / 20 °C
5.2: 1.5 h
6.1: boron tribromide / dichloromethane / -20 °C / Inert atmosphere
7.1: potassium carbonate / acetone / 6 h / Reflux; Inert atmosphere
8.1: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane; tert-butyl alcohol / 6 h / 110 °C / Inert atmosphere
With
N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); sulfuric acid; palladium diacetate; boron tribromide; potassium carbonate; caesium carbonate; trifluoroacetic anhydride; potassium hydroxide; XPhos;
In
1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jm401276h