S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine

Base Information

• Chemical Name: S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine
• CAS No.: 122748-97-4
• Molecular Formula: C₂₅H₂₄F₂N₂O₃
• Molecular Weight: 438.474
• Mol file: 122748-97-4.mol

Synonyms:

Chemical Property of S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine

There total 3 articles about S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

azalactone of N-benzoyl-p-difluoromethoxy-α-aminocinnamic acid (122748-95-2) → S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine (122748-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, triethylamine / PdCl₂ / 1,2-dimethoxy-ethane

2: 1,2-dimethoxy-ethane / 12 h

With hydrogen; triethylamine; palladium dichloride; In 1,2-dimethoxyethane;

DOI:10.1007/BF00953628

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) + azalactone of N-benzoyl-p-difluoromethoxy-α-aminocinnamic acid (122748-95-2) → S-(+)-α-phenylethylamide of N-benzoyl-p-difluoromethoxy-α-aminocinnamic acid (122748-99-6) + S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine (122748-97-4)

Guidance literature:

With hydrogen; palladium dichloride; In 1,2-dimethoxyethane; Product distribution; Rate constant; Mechanism; other solvents, in presence of triethylamine;

DOI:10.1007/BF00953628

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) + azalactone of N-benzoyl-p-difluoromethoxyphenylalanine (122749-01-3) → S,S-(-)-α-phenylethylamide of N-benzoyl-p-difluoromethoxyphenylalanine (122748-97-4)

Guidance literature:

In 1,2-dimethoxyethane; for 12h; Yield given;

DOI:10.1007/BF00953628

upstream raw materials:

(S)-1-phenyl-ethylamine

azalactone of N-benzoyl-p-difluoromethoxy-α-aminocinnamic acid

azalactone of N-benzoyl-p-difluoromethoxyphenylalanine