Technology Process of (-)-(2S,3S) ethyl 1-amino-4-benzyloxy-2,3-bis(methoxymethoxy)butane-N-carboxylate
There total 8 articles about (-)-(2S,3S) ethyl 1-amino-4-benzyloxy-2,3-bis(methoxymethoxy)butane-N-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 92 percent / triphenylphosphine/diethyl azodicarboxylate / tetrahydrofuran / 0.17 h / Ambient temperature
2: 1.) hydrazine hydrate, 2.) triethylamine / 1.) ethanol, reflux, 2.5 h; 2.) methylene dichloride, room temp., 17 h
With
hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 79 percent / sodium hydride / dimethylformamide / 1.) -40 to - 20 deg C, 0.5 h; 2.) -20 to room temp., 10 h
2: 92 percent / triphenylphosphine/diethyl azodicarboxylate / tetrahydrofuran / 0.17 h / Ambient temperature
3: 1.) hydrazine hydrate, 2.) triethylamine / 1.) ethanol, reflux, 2.5 h; 2.) methylene dichloride, room temp., 17 h
With
sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 85 percent / lithium aluminium hydride / tetrahydrofuran / 1 h / 0 °C
2: 79 percent / sodium hydride / dimethylformamide / 1.) -40 to - 20 deg C, 0.5 h; 2.) -20 to room temp., 10 h
3: 92 percent / triphenylphosphine/diethyl azodicarboxylate / tetrahydrofuran / 0.17 h / Ambient temperature
4: 1.) hydrazine hydrate, 2.) triethylamine / 1.) ethanol, reflux, 2.5 h; 2.) methylene dichloride, room temp., 17 h
With
lithium aluminium tetrahydride; sodium hydride; hydrazine hydrate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
