2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione

Base Information

• Chemical Name: 2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
• CAS No.: 1599460-88-4
• Molecular Formula: C₄₁H₅₂N₄O₅
• Molecular Weight: 680.888
• Mol file: 1599460-88-4.mol

Synonyms:

Chemical Property of 2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione

There total 1 articles about 2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

6-[1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy]hexylamine (1318250-01-9) + 4-nitronaphthalic-1,8-anhydride (6642-29-1) → 2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione (1599460-88-4)

Guidance literature:

In ethanol; for 3h; Reflux; Inert atmosphere;

DOI:10.1021/jm401874n

Reference yield: 34.0%

2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione (1599460-88-4) → 6-amino-2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione (1599460-89-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 12h; under 760.051 Torr;

DOI:10.1021/jm401874n

Reference yield:

2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-6-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione (1599460-88-4) → 6-amino-2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione hydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 760.05 Torr

2: hydrogenchloride

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol;

DOI:10.1021/jm401874n

upstream raw materials:

6-[1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy]hexylamine

4-nitronaphthalic-1,8-anhydride

Downstream raw materials:

6-amino-2-(6-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}hexyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione