C₂₁H₂₈N₆O₂

Base Information

• Chemical Name: C₂₁H₂₈N₆O₂
• CAS No.: 1207358-51-7
• Molecular Formula: C₂₁H₂₈N₆O₂
• Molecular Weight: 396.492
• Mol file: 1207358-51-7.mol

Synonyms:

Chemical Property of C₂₁H₂₈N₆O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₈N₆O₂

There total 7 articles about C₂₁H₂₈N₆O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H36N6O4 (1207358-49-3) → C21H28N6O2 (1207358-51-7)

Guidance literature:

C₂₆H₃₆N₆O₄; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

In methanol; dichloromethane; isopropyl alcohol; toluene; at 20 ℃; pH=> 7;

DOI:10.1021/jm301389h

Reference yield:

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester (57611-47-9) → C21H28N6O2 (1207358-51-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 96 h / Reflux; Inert atmosphere

2.1: trichlorophosphate / 3 h / Inert atmosphere

3.1: 2-Chloroethyl chloroformate / dichloromethane / 1.25 h / 0 - 20 °C

3.2: 0.5 h / Reflux

4.1: tetraalkylammonium carbonate polymer-bound resin / dichloromethane / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / water; acetonitrile / 120 °C / Microwave irradiation

7.1: trifluoroacetic acid / dichloromethane / 20 °C

7.2: tetraalkylammonium carbonate polymer-bound resin / 20 °C / pH > 7

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium acetate; sodium carbonate; 2-Chloroethyl chloroformate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 6.1: |Suzuki Coupling;

DOI:10.1021/jm301389h

Reference yield:

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (1208901-69-2,635698-30-5) → C21H28N6O2 (1207358-51-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetraalkylammonium carbonate polymer-bound resin / dichloromethane / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / water; acetonitrile / 120 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 20 °C

4.2: tetraalkylammonium carbonate polymer-bound resin / 20 °C / pH > 7

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3.1: |Suzuki Coupling;

DOI:10.1021/jm301389h

upstream raw materials:

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester

2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

C₁₇H₂₅ClN₄O₃

C₂₆H₃₆N₆O₄