2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

Base Information

• Chemical Name: 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride
• CAS No.: 1208901-69-2
• Molecular Formula: C7H7Cl2N3·ClH
• Molecular Weight: 240.52
• Hs Code.: 2933990090
• Mol file: 1208901-69-2.mol

Synonyms:2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine HCl;Pyrido[4,3-d]pyrimidine, 2,4-dichloro-5,6,7,8-tetrahydro-, hydrochloride (1:1);

Chemical Property of 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

Chemical Property:

• PSA: 37.81000
• LogP: 2.55990
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Hydrochloride acts as a reagent in the preparation of fused aminopyrimidines as glucose uptake inhibitors for treating parasitic and viral infections.

Technology Process of 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride

There total 8 articles about 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine (778574-06-4) → 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (1208901-69-2,635698-30-5)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In 1,2-dichloro-ethane; for 5h; Heating / reflux;

Reference yield:

C9H14O3NC6H5 (41276-30-6) → 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (1208901-69-2,635698-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / ethanol / 24 h / Heating / reflux

2: trichlorophosphate / 5 h

3: carbonochloridic acid, chloromethyl ester; triethylamine / 1,2-dichloro-ethane / 5 h / Heating / reflux

With sodium methylate; carbonochloridic acid, chloromethyl ester; triethylamine; trichlorophosphate; In ethanol; 1,2-dichloro-ethane;

Reference yield:

tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (635698-56-5) → 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (1208901-69-2,635698-30-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 15 ℃; for 15h;

upstream raw materials:

6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine

2,4-dichloro-6-(1-chloroethoxycarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester

5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione

Downstream raw materials:

C₂₅H₃₄N₆O₄

C₂₄H₂₈N₈O₂

C₂₀H₂₆N₆O₂

C₂₆H₃₆N₆O₄