(3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

Base Information

Chemical Name:(3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline
CAS No.:160189-48-0
Molecular Formula:C₁₃H₁₄FNO₂
Molecular Weight:235.258
Hs Code.:

(3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano<c>2-isoxazoline

Synonyms:

Suppliers and Price of (3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

Chemical Property:

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Technology Process of (3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

There total 1 articles about (3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3S)-2-benzyloxy-3-fluoro-5-hexenal oxime

: (3R,4S,5aR)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

: 160189-48-0
(3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

Guidance literature:: With sodium hypochlorite; triethylamine; In dichloromethane; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/0957-4166(94)80052-9

Reference yield:

: 160189-48-0
(3R,4S,5aS)-3-benzyloxy-4-fluorocyclopentano2-isoxazoline

: 160189-52-6
(1S,2R,3S,5S)-2-benzyloxy-3-fluoro-5-hydroxymethylcyclopentylamine

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl, NaBH₃CN / methanol / 3 h

2: 84 percent / H₂ / PtO₂ / methanol / 1 h

With hydrogenchloride; hydrogen; sodium cyanoborohydride; platinum(IV) oxide; In methanol;
DOI:10.1016/0957-4166(94)80052-9