Technology Process of 4-hydroxypropranolol
There total 9 articles about 4-hydroxypropranolol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine hydrochloride;
at 155 - 180 ℃;
for 1h;
DOI:10.1021/jm00135a014
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 84.1 percent / toluene / 18 h / 80 °C / with naphthalene ring-<14C>-labeled educt
2: glucose-6-phosphate; glucose-6-phosphate dehydrogenase; NADP / aq. phosphate buffer / 1.25 h / 37 °C / pH 7.4 / Enzymatic reaction; with naphthalene ring-<14C>-labeled educt and β-naphthoflavone-induced microsomes
With
glucose-6-phosphate dehydrogenase; α-D-glucose 6-phosphate; NADP;
In
phosphate buffer; toluene;
DOI:10.1021/tx960165e
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 54 percent / K2CO3 / dimethylformamide / 24 h / 60 °C / with maphthalene ring-<14C>-labeled educt
2: 84.1 percent / toluene / 18 h / 80 °C / with naphthalene ring-<14C>-labeled educt
3: glucose-6-phosphate; glucose-6-phosphate dehydrogenase; NADP / aq. phosphate buffer / 1.25 h / 37 °C / pH 7.4 / Enzymatic reaction; with naphthalene ring-<14C>-labeled educt and β-naphthoflavone-induced microsomes
With
glucose-6-phosphate dehydrogenase; α-D-glucose 6-phosphate; NADP; potassium carbonate;
In
phosphate buffer; N,N-dimethyl-formamide; toluene;
DOI:10.1021/tx960165e
