Technology Process of cis-(RS,SR)-γ-hydroxy-γ-(2-methoxyphenyl)-β-methylbutanoic acid lactone
There total 10 articles about cis-(RS,SR)-γ-hydroxy-γ-(2-methoxyphenyl)-β-methylbutanoic acid lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) toluene, THF, -78 deg C, 1 h, 2.) -78 deg C, 1 h
2: 2N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature
3: 1.) diisobutylaluminiumhydride (DIBAL-H), ZnCl2, 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methyl p-toluenesulfonate, 4-(dimethylamino)pyridine / 1.) THF, toluene, -78 deg C, 3 h, 2.) CH2Cl2, THF, RT, 18 h
With
dmap; sodium hydroxide; 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methyl toluene-p-sulphonate; potassium hexamethylsilazane; diisobutylaluminium hydride; zinc(II) chloride;
In
tetrahydrofuran; methanol;
DOI:10.1021/jo00009a030
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) toluene, THF, -78 deg C, 1 h, 2.) -78 deg C, 1 h
2: 2N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature
3: 1.) diisobutylaluminiumhydride (DIBAL-H), ZnCl2, 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methyl p-toluenesulfonate, 4-(dimethylamino)pyridine / 1.) THF, toluene, -78 deg C, 3 h, 2.) CH2Cl2, THF, RT, 18 h
With
dmap; sodium hydroxide; 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methyl toluene-p-sulphonate; potassium hexamethylsilazane; diisobutylaluminium hydride; zinc(II) chloride;
In
tetrahydrofuran; methanol;
DOI:10.1021/jo00009a030
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridinium chlorochromate (PPC), celite / CH2Cl2 / Ambient temperature
2: 1.) potassium hexamethyldisilazide (KHMDS) / 1.) toluene, THF, -78 deg C, 1 h, 2.) -78 deg C, 1 h
3: 2N NaOH / tetrahydrofuran; methanol / 2 h / Ambient temperature
4: 1.) diisobutylaluminiumhydride (DIBAL-H), ZnCl2, 2.) 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methyl p-toluenesulfonate, 4-(dimethylamino)pyridine / 1.) THF, toluene, -78 deg C, 3 h, 2.) CH2Cl2, THF, RT, 18 h
With
dmap; sodium hydroxide; 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide methyl toluene-p-sulphonate; Celite; potassium hexamethylsilazane; diisobutylaluminium hydride; pyridinium chlorochromate; zinc(II) chloride;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00009a030
