2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol

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Chemical Name:2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol
CAS No.:118226-11-2
Molecular Formula:C₃₆H₆₆O₇Si₂
Molecular Weight:667.087
Hs Code.:

2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol

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Chemical Property of 2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol

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Technology Process of 2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol

There total 11 articles about 2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 75-16-1
methylmagnesium bromide

: 118207-61-7
1-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-2-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-ethanone

: 118226-11-2
2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol

Guidance literature:: DOI:10.1021/jo00262a008

Reference yield:

: (2S,3S,4S)-2-Hydroxy-4-(4-methoxy-benzyloxy)-3-methyl-cyclohexanone

: 118226-11-2
2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

3: 1.) Pb(OAc)4, 2.) NaBH₄

5: 1.) LiEt₃BH, 2.) DMSO, (COCl)2

7: n-Bu₄NF

8: 2.) 4,5-dichloro-3,6-dioxo-1,4-cyclohexadiene-1,2-carbonitrile (DDQ)

9: 92 percent

With lead(IV) acetate; sodium tetrahydroborate; oxalyl dichloride; tetrabutyl ammonium fluoride; lithium triethylborohydride; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
DOI:10.1021/jo00262a008

Reference yield:

: 118207-45-7
(2S,3R,4S)-2-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3-methyl-cyclohexanone

: 118226-11-2
2-[(2S,4R,5R,6R)-6-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-[(1R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-3-methoxy-cyclohexyl]-propan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

2: 1.) Pb(OAc)4, 2.) NaBH₄

4: 1.) LiEt₃BH, 2.) DMSO, (COCl)2

6: n-Bu₄NF

7: 2.) 4,5-dichloro-3,6-dioxo-1,4-cyclohexadiene-1,2-carbonitrile (DDQ)

8: 92 percent

With lead(IV) acetate; sodium tetrahydroborate; oxalyl dichloride; tetrabutyl ammonium fluoride; lithium triethylborohydride; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
DOI:10.1021/jo00262a008